Can Qwen 3 235B A22B run on AMD Instinct MI350X 288GB?

YES — Runs Great

S93Excellent

○Estimated from fit model

Qwen 3 235B A22B needs ~175.9 GB VRAM. AMD Instinct MI350X 288GB has 288.0 GB. With Q4_K_M quantization, expect ~119 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 175.9 GB, 118.9 tok/s, Runs well

175.9 GB required288.0 GB available

61% VRAM used

Fit status

Runs well

Decode

118.9 tok/s

TTFT

1629 ms

Safe context

131K

Memory

175.9 GB / 288.0 GB

Memory breakdown

Weights143.4 GB

KV Cache2.9 GB

Runtime0.9 GB

Headroom28.8 GB

See how fast it feels

See how fast it feelsQwen 3 235B A22B on AMD Instinct MI350X 288GB
1st promptCold start — includes initialization
>Solve: If a train travels at 60 mph for 2.5 hours, how far does it go?
Let me work through this step by step.

Given information:
 - Speed = 60 mph (miles per hour)
 - Time = 2.5 hours

Formula: Distance = Speed x Time

Calculation:
 Distance = 60 mph x 2.5 h
 = 150 miles

The train travels 150 miles.

Double-check: at 60 mph the train covers 60 miles each hour. In half an hour it covers 30 miles. So in 2.5 hours: 60 + 60 + 30 = 150 miles. Confirmed.
2nd promptWarm — model ready, no init overhead
>What if the train stops for 20 minutes halfway?
The stop doesn't change the total distance covered while moving, but it affects total trip time.

Breakdown:
 - First half: 1.25 hours at 60 mph = 75 miles
 - Stop: 20 minutes (no distance)
 - Second half: 1.25 hours at 60 mph = 75 miles

Total distance: 150 miles (same)
Total time: 2.5 h + 0.33 h = 2.83 hours
Average speed: 150 / 2.83 = 53 mph

The distance stays the same but average speed drops to 53 mph because of the stop.
Estimated: 118.9 tok/s decode · 1.6s TTFT (warm) · 297 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	S	Runs well	118.9 tok/s	888 ms	131K
Coding	S	Runs well	118.9 tok/s	1629 ms	131K
Agentic Coding	S	Runs well	118.9 tok/s	2369 ms	131K
Reasoning	S	Runs well	118.9 tok/s	1925 ms	131K
RAG	S	Runs well	118.9 tok/s	2962 ms	131K

Quantization options

How Qwen 3 235B A22B (235B params) fits at each quantization level on AMD Instinct MI350X 288GB (288.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	91.7 GB	Low	A81
Q3_K_S	3	115.2 GB	Low	A83
NVFP4	4	131.6 GB	Medium	A84
Q4_K_M	4	143.4 GB	Medium	S85
Q5_K_M	5	169.2 GB	High	S86
Q6_KBest for your GPU	6	192.7 GB	High	S86
Q8_0	8	251.5 GB	Very High	F0
F16	16	481.7 GB	Maximum	F0

Get started

Copy-paste commands to run Qwen 3 235B A22B on your machine.

Run

lms load Qwen3-235B-A22B-Instruct-2507 && lms server start

Your hardware

More models your AMD Instinct MI350X 288GB can run

Model	Params	Grade	Decode	Capabilities
👁 Alibaba Qwen 3.5 397B A17B	397B	S	78.9 tok/s
👁 DeepSeek DeepSeek V4 Flash	284B	S	125.8 tok/s

Frequently asked questions

See all results for AMD Instinct MI350X 288GB See all hardware for Qwen 3 235B A22B

URL: https://willitrunai.com/can-run/qwen-3-235b-a22b-on-instinct-mi350x-288gb

⇱ Qwen 3 235B A22B on AMD Instinct MI350X 288GB? YES