Can Qwen3-Coder-Next run on AMD Instinct MI250X 128GB?

YES — Runs Great

S92Excellent

○Estimated from fit model

Qwen3-Coder-Next needs ~64.0 GB VRAM. AMD Instinct MI250X 128GB has 128.0 GB. With Q4_K_M quantization, expect ~155 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 64.0 GB, 168.6 tok/s, Runs well

64.0 GB required128.0 GB available

50% VRAM used

Fit status

Runs well

Decode

168.6 tok/s

TTFT

1149 ms

Safe context

256K

Memory

64.0 GB / 128.0 GB

Memory breakdown

Weights48.8 GB

KV Cache1.5 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsQwen3-Coder-Next on AMD Instinct MI250X 128GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
 if len(arr) <= 1:
 return arr
 pivot = arr[len(arr) // 2]
 left = [x for x in arr if x < pivot]
 middle = [x for x in arr if x == pivot]
 right = [x for x in arr if x > pivot]
 return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers)) # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
 """Sort a list using the quicksort algorithm.

 Args:
 arr: List of integers to sort.

 Returns:
 A new sorted list.
 """
 if len(arr) <= 1:
 return arr
 pivot = arr[len(arr) // 2]
 left = [x for x in arr if x < pivot]
 middle = [x for x in arr if x == pivot]
 right = [x for x in arr if x > pivot]
 return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 168.6 tok/s decode · 1.1s TTFT (warm) · 421 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	S	Runs well	155.0 tok/s	681 ms	256K
Coding	S	Runs well	155.0 tok/s	1249 ms	256K
Agentic Coding	S	Runs well	155.0 tok/s	1817 ms	256K
Reasoning	S	Runs well	155.0 tok/s	1476 ms	256K
RAG	S	Runs well	155.0 tok/s	2271 ms	256K

Quantization options

How Qwen3-Coder-Next (80B params) fits at each quantization level on AMD Instinct MI250X 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	31.2 GB	Low	A81
Q3_K_S	3	39.2 GB	Low	A82
NVFP4	4

Get started

Copy-paste commands to run Qwen3-Coder-Next on your machine.

Run

ollama run qwen3-coder-next

Your hardware

More models your AMD Instinct MI250X 128GB can run

Model	Params	Grade	Decode	Capabilities
👁 Mistral Devstral 2 123B Instruct	123B	S	36.2 tok/s
👁 Alibaba Qwen 3.5 122B A10B	122B	S

Frequently asked questions

See all results for AMD Instinct MI250X 128GB See all hardware for Qwen3-Coder-Next

URL: https://willitrunai.com/can-run/qwen-3-coder-next-on-instinct-mi250x-128gb

⇱