Can Qwen 3.5 4B run on AMD Instinct MI325X 256GB?

YES — Runs Great

A83Great

○Estimated from fit model

Qwen 3.5 4B needs ~31.1 GB VRAM. AMD Instinct MI325X 256GB has 256.0 GB. With Q4_K_M quantization, expect ~56 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 31.1 GB, 56.0 tok/s, Runs well

31.1 GB required256.0 GB available

12% VRAM used

Fit status

Runs well

Decode

56.0 tok/s

TTFT

3457 ms

Safe context

131K

Memory

31.1 GB / 256.0 GB

Memory breakdown

Weights2.4 GB

KV Cache2.2 GB

Runtime0.9 GB

Headroom25.6 GB

See how fast it feels

See how fast it feelsQwen 3.5 4B on AMD Instinct MI325X 256GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
 if len(arr) <= 1:
 return arr
 pivot = arr[len(arr) // 2]
 left = [x for x in arr if x < pivot]
 middle = [x for x in arr if x == pivot]
 right = [x for x in arr if x > pivot]
 return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers)) # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
 """Sort a list using the quicksort algorithm.

 Args:
 arr: List of integers to sort.

 Returns:
 A new sorted list.
 """
 if len(arr) <= 1:
 return arr
 pivot = arr[len(arr) // 2]
 left = [x for x in arr if x < pivot]
 middle = [x for x in arr if x == pivot]
 right = [x for x in arr if x > pivot]
 return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 56.0 tok/s decode · 3.5s TTFT (warm) · 140 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	56.0 tok/s	1886 ms	131K
Coding	A	Runs well	56.0 tok/s	3457 ms	131K
Agentic Coding	A	Runs well	56.0 tok/s	5029 ms	131K
Reasoning	A	Runs well	56.0 tok/s	4086 ms	131K
RAG	A	Runs well	56.0 tok/s	6286 ms	131K

Quantization options

How Qwen 3.5 4B (4B params) fits at each quantization level on AMD Instinct MI325X 256GB (256.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	1.6 GB	Low	A76
Q3_K_S	3	2.0 GB	Low	A76
NVFP4	4	2.2 GB	Medium	A76
Q4_K_M	4	2.4 GB	Medium	A76
Q5_K_M	5	2.9 GB	High	A76
Q6_K	6	3.3 GB	High	A76
Q8_0	8	4.3 GB	Very High	A76
F16Best for your GPU	16	8.2 GB	Maximum	A76

Get started

Copy-paste commands to run Qwen 3.5 4B on your machine.

Run

ollama run qwen3.5:4b

Your hardware

More models your AMD Instinct MI325X 256GB can run

Model	Params	Grade	Decode
👁 Alibaba Qwen 3.5 397B A17B	397B	A	39.2 tok/s
👁 Mistral Devstral 2 123B Instruct	123B	S	63.5 tok/s
👁 Alibaba Qwen3-Coder 30B A3B Instruct	30.5B	S	662.3 tok/s
👁 Alibaba Qwen 3.5 27B	27B	S	287.2 tok/s
👁 Alibaba Qwen 3.6 27B	27B	S	179 tok/s

Frequently asked questions

See all results for AMD Instinct MI325X 256GB See all hardware for Qwen 3.5 4B

URL: https://willitrunai.com/can-run/qwen-3.5-4b-on-instinct-mi325x-256gb

⇱ Qwen 3.5 4B on AMD Instinct MI325X 256GB? YES