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URL: https://willitrunai.com/compare?a=instinct-mi250-128gb

⇱ Compare GPUs for Local AI — Side-by-Side Hardware Analysis | Will It Run AI

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Compare local AI hardware with workload-aware output.

AMD Instinct MI250 128GB wins for coding in balanced mode

Based on model fit, speed, and quality across top recommendations.

AMD Instinct MI250 128GB

Winner
SQwen3-Coder-Next
llama.cppq8-0Runs well
100.8 GB / 128.0 GB
92.1 tok/s256K ctx
SQwen 3.5 122B A10B
llama.cppq4-k-mRuns well
90.6 GB / 128.0 GB
87.5 tok/s131K ctx
SMistral Small 4 119B
llama.cppq4-k-mRuns well
91.7 GB / 128.0 GB
94.8 tok/s124K ctx

Quick comparison

MetricAMD Instinct MI250 128GBRTX 4090 24GB
Models that fit33
Avg decode tok/s91.537.9
Best grade score9993

Operating mode: Balanced. Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

RTX 4090 24GB

SCodestral 2 25.08
llama.cppq4-k-mRuns well
19.2 GB / 24.0 GB
42.0 tok/s48K ctx
SQwen 3.6 27B
llama.cppq4-k-mTight fit
20.7 GB / 24.0 GB
31.7 tok/s69K ctx
SDevstral Small 2 24B Instruct
llama.cppq4-k-mTight fit
20.4 GB / 24.0 GB
40.0 tok/s40K ctx