AMD
AMD Instinct MI300A 128GB
InstinctDatacenterCDNA 3OAMROCm
Operating mode
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Use this to bias workload recommendations toward responsiveness, background autonomy, lighter serving, or multi-GPU scale-out.
Current mode
Balanced
Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.
About this GPU for AI
The AMD Instinct MI300A 128GB is a unique APU-style CDNA 3 accelerator combining CPU cores (Zen 4) and GPU compute on the same package with a unified 128 GB HBM3 memory pool. Unlike the discrete MI300X, the MI300A's memory is shared between CPU and GPU — eliminating PCIe transfer overhead for AI workloads where CPU preprocessing and GPU inference must cooperate. It delivers 1.2 PFLOPS FP16 with 5.3 TB/s of memory bandwidth.
Beyond LLMs
AI Capability Matrix
What AI tasks this GPU can handle — from text generation to image and video creation.
| Capability | Status | Representative Model | Detail |
|---|
| LLM Chat (7B) | Runs natively | Llama 3.1 8B Q4 | — |
| LLM Coding (30B) | Runs natively | Qwen 3 30B Q4 | — |
| LLM Large (70B) |
rocm-supporteddatacenter-gradehigh-bandwidthhigh-vramapu-design
Specifications
Compute
FP161200 TFLOPS
INT82400 TOPS
ArchitectureCDNA 3
Memory
VRAM128 GB
Bandwidth5300 GB/s
General
FamilyInstinct
SegmentDatacenter
InterconnectOAM
Compute PlatformROCM
MSRP$12,000
Key Features
CDNA 3 architecture (APU design — Zen 4 CPU + CDNA 3 GPU on one package)128 GB HBM3 in a unified CPU+GPU memory pool5.3 TB/s memory bandwidth (shared CPU/GPU)228 Compute Units with third-generation Matrix Cores (FP8 support)AMD Infinity Fabric — zero-copy CPU-GPU data sharingFull ROCm support — AMD's coherent AI computing platform
For AI Workloads
Strengths
- Unified CPU-GPU memory eliminates PCIe bottleneck for heterogeneous workloads
- 5.3 TB/s HBM3 bandwidth is excellent for large model decode
- FP8 support in CDNA 3 Matrix Cores enables aggressive quantization
- 128 GB shared memory covers 70B FP16 models in unified inference+preprocessing
Considerations
- CPU and GPU share the 128 GB pool — GPU gets less if CPU uses significant memory
- OAM/specialized server form factor — not a drop-in PCIe card
- More complex deployment than discrete GPU + CPU configurations
- ROCm unified memory programming model requires software adaptation
CDNA 3 powers the Instinct MI300X (GPU-only, 192 GB HBM3) and MI300A (APU with integrated CPU). It features advanced packaging with up to 12 chiplets and native FP8 support for AI inference.
AI Relevance
The MI300X with 192 GB HBM3 can hold even the largest open-weight models (70B+ at full precision) entirely in GPU memory. FP8 support and mature ROCm stack make it a serious competitor to NVIDIA H100 for AI inference.
Process: TSMC 5nm + 6nmPlatform: ROCMPrecisions: FP64, FP32, TF32, FP16, BF16, FP8, INT8
Recommendations by Workload
Qwen 3.5 122B A10B matches Chat and keeps a practical fit profile. It is a recent-generation family, which helps on current local SOTA workloads. It fits natively with comfortable headroom. Context coverage stays within the requested workload envelope. Known distribution channels: huggingface, lm-studio.
Decode 149.2 tok/s · 131K ctx · llama.cppEST.
Qwen3-Coder-Next is a specialized fit for Coding. It is a recent-generation family, which helps on current local SOTA workloads. It fits natively with comfortable headroom. Context coverage stays within the requested workload envelope. Known distribution channels: huggingface, ollama, lm-studio.
Decode 157.1 tok/s · 256K ctx · llama.cppEST.
Just out of reach
Models you could run with an upgrade
High-quality models that need a bit more memory
397BTier 100Needs ~257.3 GB
Also runs on 2× your GPU via Infinity Fabric — 59 tok/s
1000BTier 100Needs ~627.4 GB
1000BTier 100Needs ~627.4 GB
1600BTier 100Needs ~876.6 GB
284BTier 98Needs ~172.4 GB
Also runs on 2× your GPU via Infinity Fabric — 141 tok/s
Image & Video Generation
Diffusion Model Compatibility
52 of 52 models can generate images or video on your AMD Instinct MI300A 128GB
Multi-GPU scaling
AMD Instinct MI300A 128GB — Up to 4× via Infinity Fabric
Scale out with multiple GPUs for larger models. Infinity Fabric provides 896 GB/s inter-GPU bandwidth with 12% overhead.
| Config | Effective memory | Models that fit | Est. bandwidth |
|---|
| 1× AMD | 128 GB | 351/374 | 5,300 GB/s |
| 2× AMD | 256 GB | 363/374 | 9,328 GB/s |
| 4× AMD | 512 GB | 371/374 | 18,656 GB/s |
Model counts use default quantization at coding workload settings. Multi-GPU scaling factor: 0.88× per additional GPU.
Upgrade paths
Upgrade from AMD Instinct MI300A 128GB
See what you unlock with more powerful hardware
Upgrade options
Upgrade options
4× AMD Instinct MI300A 128GBMulti-GPU
4 × 128 GB = 512 GB effectivevia Infinity Fabric (896 GB/s)
AUnlocks 20 additional models that do not fit on the current setup.Unlocks Qwen 3.5 397B A17B, DeepSeek V4 Flash, GLM-5.1+17 more · +62% faster avg
Unlocks 20 additional models that do not fit on the current setup.
Lifts average decode speed across fitting models by about 62%.
Infinity Fabric gives this scale-out path a cleaner inter-GPU story than PCIe-only builds.
~$12,000 MSRP
141 GB VRAM (+13)
BUnlocks 2 additional models that do not fit on the current setup.Unlocks Qwen 3 235B A22B, MiniMax M2.7+3% faster avg
Unlocks 2 additional models that do not fit on the current setup.
~$30,000 MSRP
180 GB VRAM (+52)8000 GB/s (+2700)
BUnlocks 8 additional models that do not fit on the current setup.Unlocks DeepSeek V4 Flash, Qwen 3 235B A22B, MiniMax M2.7+5 more · +26% faster avg
Unlocks 8 additional models that do not fit on the current setup.
Lifts average decode speed across fitting models by about 26%.
~$30,000 MSRP
AMD Instinct MI325X 256GBAMD upgrade
256 GB VRAM (+128)6000 GB/s (+700)
BUnlocks 12 additional models that do not fit on the current setup.Unlocks Qwen 3.5 397B A17B, DeepSeek V4 Flash, Qwen 3 235B A22B+9 more · +5% faster avg
Unlocks 12 additional models that do not fit on the current setup.
~$20,000 MSRP
AMD Instinct MI350X 288GBBest value
288 GB VRAM (+160)8000 GB/s (+2700)
BUnlocks 13 additional models that do not fit on the current setup.Unlocks Qwen 3.5 397B A17B, DeepSeek V4 Flash, Qwen 3 235B A22B+10 more · +18% faster avg
Unlocks 13 additional models that do not fit on the current setup.
Lifts average decode speed across fitting models by about 18%.
~$8,000 MSRP
Frequently Asked Questions
AMD Instinct MI300A 128GBCategory AvgNVIDIA H200 141GB
| Image Gen (SDXL) | Runs natively | SDXL 1.0 FP16 | ~300ms per image |
| Image Gen (Flux) | Runs natively | Flux.1 Dev FP16 | ~~1.3s per image |
| Image Gen (SD 3.5) | Runs natively | SD 3.5 Large FP16 | ~~1.6s per image |
| Video Short (25f) | Runs natively | LTX Video 2B | ~300ms/frame |
| Video Long (100f) | Runs natively | Wan Video 14B | ~800ms/frame |
S
Devstral 2 123B Instruct is a specialized fit for Agentic Coding. It is a recent-generation family, which helps on current local SOTA workloads. It fits natively with comfortable headroom. Context coverage stays within the requested workload envelope. Known distribution channels: huggingface, lm-studio.
Decode 53.8 tok/s · 117K ctx · llama.cppEST.
Devstral 2 123B Instruct matches Reasoning and keeps a practical fit profile. It is a recent-generation family, which helps on current local SOTA workloads. It fits natively with comfortable headroom. Context coverage stays within the requested workload envelope. Known distribution channels: huggingface, lm-studio.
Decode 53.8 tok/s · 117K ctx · llama.cppEST.
Qwen 3.5 122B A10B matches RAG and keeps a practical fit profile. It is a recent-generation family, which helps on current local SOTA workloads. It fits natively with comfortable headroom. Context coverage stays within the requested workload envelope. Known distribution channels: huggingface, lm-studio.
Decode 149.2 tok/s · 131K ctx · llama.cppEST.
97
119B91.7 GB162 tok/s124K ctx
Image
| MAGI-1Video | 1280×720 | 700ms/frame | S |
Image models estimated at 1024×1024 (28 steps, FP16). Video models estimated at 768×512 (25 frames, 30 steps, FP16). Actual performance varies with runtime and system load.
Buying advice
Should you buy AMD Instinct MI300A 128GB for local AI?
Excellent choice for local AI
Runs 36 of 50 top models well — a strong all-rounder for local inference.
What will limit you first
This setup is broadly balanced for this model.
No major red flags
This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.
Best upgrade itinerary
Unlocks 2 additional models that do not fit on the current setup.
Want more headroom? NVIDIA H200 141GB (141.0 GB VRAM) is the next step up.