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⇱ CYCLOPHOSPHAMIDE Definition & Meaning | Dictionary.com


cyclophosphamide

American  
[sahy-kluh-fos-fuh-mahyd, -mid, sik-luh-] / ˌsaɪ kləˈfɒs fəˌmaɪd, -mɪd, ˌsɪk lə- /

noun

Pharmacology.
  1. a synthetic, crystalline, toxic substance, C 7 H 15 Cl 2 N 2 O 2 P, related to nitrogen mustard, used in the treatment of Hodgkin's disease, lymphoma, and certain leukemias. CYC


cyclophosphamide British  
/ ˌsaɪkləʊˈfɒsfəˌmaɪd /

noun

  1. an alkylating agent used in the treatment of leukaemia and lymphomas

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of cyclophosphamide

First recorded in 1955–60; cyclo- + phosph- + amide

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

From there, Eisman was diagnosed, underwent a double mastectomy and is being treated with two types of chemotherapy: Taxol and AC, or Adriamycin and cyclophosphamide.

From MarketWatch • Dec. 12, 2025

Nice said the drug cost £4,320 for a 1,800mg per 15ml vial and, along with bortezomib, cyclophosphamide and dexamethasone, was recommended as an option for treating newly diagnosed AL amyloidosis in adults.

From BBC • Mar. 4, 2024

A component of the chemotherapy, cyclophosphamide, also suppresses regulatory T cells, which inhibit killer T cell responses.

From Science Daily • Sep. 21, 2023

Brodsky explains that cyclophosphamide does not harm the engrafted stem cells, as these produce an enzyme called aldehyde dehydrogenase that renders them resistant to it.

From Nature • Nov. 11, 2014

It remains unclear whether the secret to Ildstad's recipe is the facilitating cells or the timing of a certain chemotherapy drug, called cyclophosphamide, that is used to prevent graft rejection and GvHD.

From Scientific American • Mar. 7, 2012

Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023

Idioms from The American Heritage® Idioms Dictionary copyright © 2002, 2001, 1995 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company.