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⇱ SUBSTRATE Definition & Meaning - Merriam-Webster


2
: the base on which an organism lives
the soil is the substrate of most seed plants
3
: a substance acted upon (as by an enzyme)
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With its Latin prefix sub-, "below", substrate obviously refers to a layer under something else. Rock may serve as the substrate for the coral in a coral reef. Tiny wafers of silicon (or another semiconductor) serve as the substrate for computer chips. Substrate may also mean subsoil—that is, the layer under the topsoil, lacking in organic matter or humus. Substrate is part of the vocabulary of various other sciences, including chemistry and biology. But although it's mostly a scientific term, writers may also use it to mean simply "foundation"—for instance, when observing that reading is the substrate on which most other learning is based.

Examples of substrate in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
These spike trains often appear when fungi interact with their environment, such as encountering wood or other substrates. 👁 Image
Samantha Agate, Kansas City Star, 30 Mar. 2026
The preferred substrate of the lion’s mane mushroom is large old beech or oak trees—although it has also been found growing on other hardwood trees, such as maple and ash, and on younger trees as well as on stout logs and stumps of dead wood. 👁 Image
Encyclopedia Britannica, 27 Mar. 2026
His laboratory has worked for many years on the cellular substrates of memory storage in the brain and a few other topics. 👁 Image
Big Think, 27 Mar. 2026
Roll-to-roll coating methods are preferred in industry because the coatings are applied continuously to large rolls of a substrate material, such as paper or other biodegradable plastics. 👁 Image
J. Carson Meredith, The Conversation, 17 Mar. 2026
See All Example Sentences for substrate

Word History

Etymology

Medieval Latin substratum

First Known Use

1730, in the meaning defined at sense 1

Time Traveler
The first known use of substrate was in 1730

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Cite this Entry

“Substrate.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/substrate. Accessed 8 Apr. 2026.

Kids Definition

1
: an underlying layer: as
b
: the base on which an organism lives or over which it moves
the soil is the substrate of most plants
2
: a substance acted upon (as by an enzyme)

Medical Definition

2
: the base on which an organism lives
3
: a substance acted upon (as by an enzyme)

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