Time after PDT (h) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Adhesion molecule | None | HPPH | 0 | 1 | 3 | 6 (PDT) | 6 (Untx) a | 8 | 12 | 24 | 48 |
E-selectin (CD62E) | −b | − | −/± | −/± | −/+ | −/+++ | − | −/+ | −/± | −/± | − |
ICAM-1 (CD54) | −/± | −/± | −/+ | −/+ | −/++ | −/± | −/++ | −/++ | −/+ | −/+ | −/± |
PECAM-1 CD31 | +++ | +++ | +++ | +++ | +++ | ++++ | +++ | ++ | −/++ | NDc | ND |
- aUntx refers to the contralateral tumour that was not treated with light in animals receiving HPPH and having one tumour treated with light.
- bStaining intensity of tumour microvessels ranges from undetectable (−) to very high levels (++++).
- cND, not determined.