A preprint by Teodoro-Castro et al. reports a nuclear role for STING in impairing DNA replication and contributing to replication stress in ageing pathologies.

Functional profiling of autoantibodies from individuals with long COVID demonstrates a casual link with neurological symptoms, reframing long COVID as, at least in part, an antibody-mediated disease.

A study in Science uses intravital microscopy to analyse the septic process in real time in mouse lung, showing that immunothrombus formation is associated with early pathology and mortality but later protection from disease through bacterial trapping.

A preprint by Alberts et al. shows that extrafollicular plasma cells suppress dendritic cell activation and trafficking in tumour-draining lymph nodes, which results in failure to establish an antitumour memory T cell response in immune-cold, triple-negative breast cancer.

Immunological memory has long been framed through a temporal lens, defined by the persistence and rapid recall responses of antigen-experienced lymphocytes. Drawing on the neuroscience concept of the engram, I propose the immune engram as a spatial model of memory. Here, tissue-anchored, antigen-gated multicellular circuits are selectively reconstructed upon re-exposure to cognate antigen. I further outline engram tracing and circuit reprogramming as testable directions for characterizing, tracing and therapeutically reconfiguring immune memory in disease settings.

A preprint by Farzad et al. reports a cellular senescence atlas of human lymph nodes from donors aged 18 to 86, showing that B cells are the main senescent population to accumulate with age.