Clinical microbiology articles from across Nature Portfolio

In this work, authors show that the loss of the carbapenem porin OprD in Pseudomonas aeruginosa reduces mucus entrapment and enhances airway epithelial barrier crossing, illustrating how antibiotic resistance mutations can reshape infection dynamics beyond drug resistance.

Parkinson’s disease is managed through co-treatment with levodopa and tolcapone, with tolcapone altering the microbiome to increase its capacity to metabolize levodopa, implicating the gut microbiome in drug–drug interaction.

Here, in a two-phase population trial, the authors show that composite polyphenols intervention could mitigate the increase in pro-inflammatory indicators associated with high microplastic exposure by modulating gut microbiota and up-regulating glycerophospholipid metabolism pathways.

Pulmonary microbiotacomponents in bronchiectasis patients receive repeated antibiotic exposures, whereas previous studies on the effects ofantibiotic treatment focused on typical pathogens rather than commensals. By integrating experimental evolution withsingle-cell resolution, the authors reveal a multifaceted strategy by which Neisseria subflava, a common airwaycommensal associated with bronchiectasis, exploits antibiotic selection to transition towards pathogenicity.

Locally relevant use cases can maximize national support for genomic sequencing in low- and middle-income countries.

This study reports the structure, specificity and genotoxic activity of colibactin.

This study shows that regional mismatches between transplanted microbiota and the host gut environment alter the metabolic and immune states of host tissues as well as the composition of regional microbiomes.

Microbial-based and microorganism-targeting therapies are emerging to prevent or treat preterm infant complications, but more preclinical research and clinical evidence is needed.

In this study, Ryan et al. underscore the role of a balanced gut microbiota in infant immunity and responses to vaccination.