Diseases articles from across Nature Portfolio

CAR T cell therapy can induce deep responses but also severe toxicities in patients with smoldering myeloma, an asymptomatic cancer precursor; given the potential risks and benefits, its success depends on careful patient selection.

B cells display a range of effector and memory phenotypes, antibody isotypes and affinities. We show that during malaria parasite infection, individual, activated clones commonly combine early, class-switch recombination, clonal expansion, effector fate bifurcation and somatic hypermutation to rapidly diversify in vivo.

Psychiatric disorders are heterogeneous, and care depends on interpreting unstructured longitudinal narratives, creating variability that hinders standardization. A study now shows that a psychiatry-specific large language model (LLM) may help clinicians to deliver more consistent, high-quality care.

Having a greater tissue volume in some parts of the cerebellum is linked to higher scores on cognitive tests.

Analysis shows evidence of deadly outbreaks 5,500 years ago — plus, a prototype dark-matter detector.

In my view, we have never had as robust a body of evidence from observational data on an intervention for dementia as we do for live-attenuated shingles vaccination. Both a recent US National Institutes of Health expert workshop and an international expert consensus on Alzheimer’s disease drug repurposing identified large-scale randomized trials of shingles vaccination for dementia prevention as the crucial next step for the field.

CAR T cell therapy can induce deep responses but also severe toxicities in patients with smoldering myeloma, an asymptomatic cancer precursor; given the potential risks and benefits, its success depends on careful patient selection.