Vaccines articles from across Nature Portfolio

Crosslinked ionizable lipids enable mRNA lipid nanoparticles to metabolically reprogram immune cells to elicit strong vaccine responses while reducing inflammatory side effects.

Porcine circovirus type 3 threatens swine health and lacks dedicated vaccines. Here, authors define PCV3 VLP structures and antibody recognition and show that VLP vaccination elicits durable protection in pigs.

This study compares the humoral response of individuals who received inactivated influenza vaccines to that of individuals who received an mRNA-based quadrivalent influenza vaccine. The mRNA-based vaccine induced prolonged germinal center responses, more antibodies and increased numbers of memory B cells.

Polysaccharide vaccines are crucial to immunize against bacterial infections but require efficacious adjuvants to induce protective immune responses. Here the authors explore the use of Pam3CSK4 as an adjuvant for polysaccharide vaccines in mouse and non-human primate models.

Chen and colleagues identify that baseline IFNβ levels correlate with antibody responses to inactivated influenza vaccines in humans, and show that type I IFNs, IL-12 and IL-21 functionally enhance antibody responses in human organoids.

Here the authors characterize mRNA-based tuberculosis vaccine candidates BNT164a1 and BNT164b1 and show that they are immunogenic, well tolerated and efficacious in preclinical animal models.

Cryo-EM structures of native trimeric MOMP isolated from chlamydial infectious bodies show a distinct 10-stranded beta-barrel architecture that explains antibody recognition, disproves porin function, and guides structure-based vaccine design.

Crosslinked ionizable lipids enable mRNA lipid nanoparticles to metabolically reprogram immune cells to elicit strong vaccine responses while reducing inflammatory side effects.

The shot reduced insulin use for people with type 1 diabetes and another autoimmune condition.

Sustaining and transitioning mpox vaccination requires establishing and resourcing a global mpox vaccine stockpile under the Inter-Agency Coordinating Group (ICG), supported by sustainable financing, transparent allocation criteria, diversified manufacturing (including local production in Africa), and robust logistics, surveillance, and operational systems. Moreover, it requires strengthened collaboration among global, regional, and community actors; continuous data generation and research to inform policy, including genomic and vaccine effectiveness studies; and accelerated R&D with fast-tracked local manufacturing to enhance supply resilience and long-term epidemic preparedness.

Quick identification of viruses holds the key to minimizing their spread.

RNA-based and RNA-targeting therapeutics have emerged as an important component of modern medicine development. Here, Nature Chemical Biology speaks to Maria Duca, Samie Jaffrey and Ling-Ling Chen about the most promising breakthroughs and the persistent technical hurdles involved in translating basic RNA research into clinical therapies. We discuss how emerging technologies, strategic funding and cross-sector collaborations are essential to overcome current bottlenecks and advance the clinical application of RNA-centered medicines.

The deadly disease was identified half a century ago in the Democratic Republic of the Congo. It is unacceptable that it continues to take lives.