Virology articles from across Nature Portfolio

A nanoparticle adjuvant that safely targets the STING pathway via intranasal administration generates potent mucosal and systemic immunity against diverse coronaviruses in preclinical models and converts existing intramuscular flu vaccines into effective nasal sprays.

Tracking influenza virus populations over 72 passages, the authors show that hundreds of defective viral genomes compete for dominance, ultimately resolving into a single variant carrying an adaptive mutation that enhances replication and interference, enabling it to outcompete other defective genomes.

Porcine circovirus type 3 threatens swine health and lacks dedicated vaccines. Here, authors define PCV3 VLP structures and antibody recognition and show that VLP vaccination elicits durable protection in pigs.

This study reveals a novel, druggable route for SARS-CoV-2 infection and inflammatory responses in macrophages, thus expanding our understanding of COVID-19 pathogenesis and demonstrating a therapeutic target for infectious diseases.

The lattice architecture of the HIV capsid holds the key to understanding its biophysical properties and function. Li et al. introduce a geometric criterion revealing its implications for molecular frustration, lattice anomalies and cofactor binding.

In a cerebral organoid model, Ebola virus persists by infecting neurons, astrocytes and microglia, driving local inflammation, cell-specific responses, viral adaptation and cell-to-cell spread.

Quick identification of viruses holds the key to minimizing their spread.

The deadly disease was identified half a century ago in the Democratic Republic of the Congo. It is unacceptable that it continues to take lives.

Nature staff discuss ongoing efforts to curb the Bundibugyo virus outbreak.

Public-health researcher James Baguma has studied the interactions between bats, which can carry the virus, and people in the region near the latest epidemic.

The size of the outbreak in its initial days is worrying researchers. The next few weeks will determine how large it grows, they say.