Sabrent USB 3.2 Enclosure + Sabrent Rocket Q 2TB NVMe SSD On Linux Performance
For Google's LevelDB key-value storage library, the performance ended up being similar both when the Rocket Q 2TB was connected directly to the system and via USB 3.2.
SQLite also yielded similar performance between the two interfaces.
And for moderate I/O tasks like building the Linux kernel source tree from said NVMe SSD, the build time was similar in that real-world case.