ZFIN is now using GRCz12tu for Genomic Data
Gene
ercc2
- ID
- ZDB-GENE-040426-997
- Name
- excision repair cross-complementation group 2
- Symbol
- ercc2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA helicase activity and damaged DNA binding activity. Predicted to be involved in positive regulation of mitotic recombination and transcription by RNA polymerase II. Predicted to act upstream of or within DNA repair. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; female organism; gonad; male organism; and precaudal vertebra. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; acquired immunodeficiency syndrome; carcinoma (multiple); hematologic cancer (multiple); and xeroderma pigmentosum (multiple). Orthologous to human ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
👁 Image
Expression
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype
- All Phenotype Data
- 7 figures from Ma et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ercc2 Human Ortholog
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cerebrooculofacioskeletal syndrome 2 | Alliance | ?Cerebrooculofacioskeletal syndrome 2 | 610756 |
| photosensitive trichothiodystrophy 1 | Alliance | Trichothiodystrophy 1, photosensitive | 601675 |
| xeroderma pigmentosum group D | Alliance | Xeroderma pigmentosum, group D | 278730 |
Associated With ercc2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR002464 | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site |
| Domain | IPR006554 | Helicase-like, DEXD box c2 type |
| Domain | IPR006555 | ATP-dependent helicase, C-terminal |
| Domain | IPR010614 | RAD3-like helicase, DEAD |
| Domain | IPR010643 | Helical and beta-bridge domain |
| Domain | IPR014013 | Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type |
| Family | IPR001945 | RAD3/XPD |
| Family | IPR013020 | ATP-dependent helicase Rad3/Chl1-like |
| Family | IPR045028 | Helicase superfamily 1/2, DinG/Rad3-like |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Additional Resources | Length | ATP-dependent helicase, C-terminal | ATP-dependent helicase Rad3/Chl1-like | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site | Helical and beta-bridge domain | Helicase-like, DEXD box c2 type | Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type | Helicase superfamily 1/2, DinG/Rad3-like | P-loop containing nucleoside triphosphate hydrolase | RAD3-like helicase, DEAD | RAD3/XPD |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1Q5E7 | InterPro | 760 |
Transcripts
- Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
- Genome Browsers
Orthology
Citations