Left Hand is a symbiote lodged in the hand of the
D.
Suspicions abound as to what exactly the left hand is. He is referred as being a part of the same species as one of the Barbaroi. Left Hand belongs to a species of (normally) malevolent parasites that inhabit different parts of the human body. Despite this, Left Hand is as unique in his abilities among his people as D is among other dhampirs. Whether this is due to being in the body of a dhampir or that he was a servant of D's father is unknown.
Left Hand, does though perform many important duties in the story. He uses to D's advantage his special psychic abilities, and often extracts truth and veritable bits of information that aid D on his wanderings.
In terms of personality, Left Hand tends to be a stark contrast to the stoic D, often making sarcastic remarks or cracking jokes. The two appear to have been together a long time as Left Hand talks about D's heritage and past though D often quickly shuts him up if he tries to mention his father.