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URL: https://www.jci.org/articles/view/115743

⇱ JCI - Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype.

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Research Article Free access | 10.1172/JCI115743

Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype.

M Santoro, F Carlomagno, I D Hay, M A Herrmann, M Grieco, R Melillo, M A Pierotti, I Bongarzone, G Della Porta, and N Berger

Centro di Endocrinologia ed Oncologia, Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.

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Centro di Endocrinologia ed Oncologia, Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.

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Centro di Endocrinologia ed Oncologia, Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.

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Centro di Endocrinologia ed Oncologia, Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.

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Centro di Endocrinologia ed Oncologia, Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.

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Centro di Endocrinologia ed Oncologia, Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.

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Centro di Endocrinologia ed Oncologia, Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.

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Centro di Endocrinologia ed Oncologia, Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.

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Centro di Endocrinologia ed Oncologia, Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.

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Centro di Endocrinologia ed Oncologia, Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.

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Published May 1, 1992 - More info

Published in Volume 89, Issue 5 on May 1, 1992
J Clin Invest. 1992;89(5):1517–1522. https://doi.org/10.1172/JCI115743.
© 1992 The American Society for Clinical Investigation
Published May 1, 1992 - Version history
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Abstract

We have recently reported the activation of a new oncogene in human papillary thyroid carcinomas. This oncogene, papillary thyroid carcinoma (PTC), is a novel rearranged version of the ret tyrosine-kinase protooncogene. Thyroid neoplasms include a broad spectrum of malignant tumors, ranging from well-differentiated tumors to undifferentiated anaplastic carcinomas. To determine the frequency of ret oncogene activation, we analyzed 286 cases of human thyroid tumors of diverse histologic types. We found the presence of an activated form of the ret oncogene in 33 (19%) of 177 papillary carcinomas. By contrast, none of the other 109 thyroid tumors, which included 37 follicular, 15 anaplastic, and 18 medullary carcinomas, and 34 benign lesions, showed ret activation.

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Version history
  • Version 1 (May 1, 1992): No description
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