VOOZH about

URL: https://en.wikipedia.org/wiki/SLC13A3

⇱ SLC13A3 - Wikipedia

Jump to content
From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
SLC13A3
Identifiers
AliasesSLC13A3, NADC3, SDCT2, solute carrier family 13 member 3, ARLIAK
External IDsOMIM: 606411; MGI: 2149635; HomoloGene: 11266; GeneCards: SLC13A3; OMA:SLC13A3 - orthologs
Gene location (Human)
👁 Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Band20q13.12Start46,557,823 bp[1]
End46,684,467 bp[1]
Gene location (Mouse)
👁 Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Band2|2 H3Start165,246,948 bp[2]
End165,315,150 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • kidney tubule

  • metanephric glomerulus

  • oocyte

  • secondary oocyte

  • olfactory bulb

  • human kidney

  • C1 segment

  • corpus callosum

  • right lobe of liver

  • placenta
Top expressed in
  • median eminence

  • retinal pigment epithelium

  • human kidney

  • right kidney

  • Rostral migratory stream

  • proximal tubule

  • pontine nuclei

  • mammillary body

  • olfactory tubercle

  • arcuate nucleus
More reference expression data
BioGPS
👁 Image


👁 Image
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64849

114644

Ensembl

ENSG00000158296

ENSMUSG00000018459

UniProt

Q8WWT9

Q91Y63

RefSeq (mRNA)

NM_022829
NM_001011554
NM_001193339
NM_001193340
NM_001193342

NM_054055

RefSeq (protein)

NP_001011554
NP_001180268
NP_001180269
NP_001180271
NP_073740

NP_473396

Location (UCSC)Chr 20: 46.56 – 46.68 MbChr 2: 165.25 – 165.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 13 member 3 also called sodium-dependent dicarboxylate transporter (NaDC3) is a protein that in humans is encoded by the SLC13A3 gene.[5][6][7]

Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.[7]

See also

[edit]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158296 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018459 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wang H, Fei YJ, Kekuda R, Yang-Feng TL, Devoe LD, Leibach FH, Prasad PD, Ganapathy V (Jun 2000). "Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter". Am J Physiol Cell Physiol. 278 (5): C1019–30. doi:10.1152/ajpcell.2000.278.5.C1019. PMID 10794676. S2CID 39532742.
  6. ^ Huang W, Wang H, Kekuda R, Fei YJ, Friedrich A, Wang J, Conway SJ, Cameron RS, Leibach FH, Ganapathy V (Nov 2000). "Transport of N-acetylaspartate by the Na(+)-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain". J Pharmacol Exp Ther. 295 (1): 392–403. PMID 10992006.
  7. ^ a b "Entrez Gene: SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3".

Further reading

[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

By group
SLC1–10
(1):
(2):
(3):
(4):
(5):
(6):
(7):
(8):
(9):
(10):
SLC11–20
(11):
(12):
(13):
(14):
(15):
(16):
(17):
(18):
(19):
(20):
SLC21–30
(21):
(22):
(23):
(24):
(25):
(26):
(27):
(28):
(29):
(30):
SLC31–40
(31):
(32):
(33):
(34):
(35):
(36):
(37):
(38):
(39):
(40):
SLC41–48
(41):
(42):
(43):
(44):
(45):
(46):
(47):
(48):
SLCO1–4
Symporter, Cotransporter
Antiporter (exchanger)


👁 Stub icon

This membrane protein–related article is a stub. You can help Wikipedia by adding missing information.

Categories:
Hidden categories: