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URL: https://en.wikipedia.org/wiki/SLC9A10

⇱ Sodium/hydrogen exchanger 10 - Wikipedia


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Protein-coding gene in the species Homo sapiens
SLC9C1
Identifiers
AliasesSLC9C1, NHE, SLC9A10, sperm-NHE, NHE-10, solute carrier family 9 member C1
External IDsOMIM: 612738; MGI: 2685456; HomoloGene: 19505; GeneCards: SLC9C1; OMA:SLC9C1 - orthologs
Gene location (Human)
πŸ‘ Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Band3q13.2Start112,140,898 bp[1]
End112,294,227 bp[1]
Gene location (Mouse)
πŸ‘ Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Band16|16 B5Start45,355,672 bp[2]
End45,427,364 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • body of pancreas

  • left testis

  • right testis

  • gonad

  • skin of abdomen

  • skin of leg

  • left ventricle

  • apex of heart

  • left lobe of thyroid gland
Top expressed in
  • spermatocyte

  • spermatid

  • testicle

  • islet of Langerhans
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

285335

208169

Ensembl

ENSG00000172139
ENSG00000285044

ENSMUSG00000033210

UniProt

Q4G0N8

Q6UJY2

RefSeq (mRNA)

NM_183061
NM_001320531

NM_198106

RefSeq (protein)

NP_001307460
NP_898884

NP_932774

Location (UCSC)Chr 3: 112.14 – 112.29 MbChr 16: 45.36 – 45.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sodium/hydrogen exchanger 10, also known as solute carrier family 9 member 10, is a protein that in humans is encoded by the SLC9A10 gene.[5][6]

Function

[edit]

SLC9A10 is a member of the sodium-hydrogen exchanger (NHE) family and is required for male fertility and sperm motility.[5][7]

References

[edit]
  1. ^ a b c ENSG00000285044 GRCh38: Ensembl release 89: ENSG00000172139, ENSG00000285044 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033210 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: solute carrier family 9".
  6. ^ Oduru S, Campbell JL, Karri S, Hendry WJ, Khan SA, Williams SC (June 2003). "Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs". BMC Genomics. 4 (1): 22. doi:10.1186/1471-2164-4-22. PMC 161800. PMID 12783626.
  7. ^ Wang D, King SM, Quill TA, Doolittle LK, Garbers DL (December 2003). "A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility". Nature Cell Biology. 5 (12): 1117–22. doi:10.1038/ncb1072. PMID 14634667. S2CID 12912080.