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General Information

Symbol

Dmel\porin^JF03251

Species

D. melanogaster

Name

FlyBase ID

FBal0242427

Feature type

allele

Associated gene

Dmel\porin

Associated Insertion(s)

Carried in Construct

P{TRiP.JF03251}

Also Known As

UAS-Porin-RNAi, Porin RNAi, UAS-porin RNAi

Key Links

👁 Image

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF03251}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF03251

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neurodegenerative disease

CEA

(M'Angale and Staveley, 2016)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease 6

modeled by Pink1^B9

(Lee et al., 2018)

ameliorates Parkinson's disease

modeled by Miro^UAS.Tag:MYC

(Lee et al., 2018)

ameliorates neurodegenerative disease

modeled by par-1^UAS.cUa

(Lee et al., 2018)

model of neurodegenerative disease

is ameliorated by Buffy^UAS.cQa

(M'Angale and Staveley, 2016)

exacerbates Parkinson's disease 1

modeled by Hsap\SNCA^UAS.cFa

(M'Angale and Staveley, 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | third instar larval stage, with Scer\GAL4^Cg.PA

(Zhou et al., 2019)

Phenotype Manifest In

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^Cg.PA

(Zhou et al., 2019)

mitochondrion | third instar larval stage, with Scer\GAL4^Cg.PA

(Zhou et al., 2019)

Detailed Description

Statement

Reference

Expressing porin^JF03251 under the control of Scer\GAL4^Cg.PA leads to fragmented mitochondria in the third instar larval fat body (as assessed by MitoGFP).

(Zhou et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

porin^JF03251/Scer\GAL4^GMR.PFa is a non-enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PFa, Tom40^{UAS.Tag:FLAG,Tag:HA}

(Periasamy et al., 2022)

Suppressor of

Statement

Reference

porin^JF03251, Pisd^GMR.PZ, Scer\GAL4^GMR.long is a suppressor of decreased cell number | somatic clone | progressive phenotype of Pect²⁹, Scer\FLP1^ey.PU

(Zhao and Wang, 2020)

NOT Suppressor of

Statement

Reference

porin^JF03251/Scer\GAL4^GMR.PFa is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PFa, Tom40^{UAS.Tag:FLAG,Tag:HA}

(Periasamy et al., 2022)

porin^JF03251/Scer\GAL4^Cg.PA is a non-suppressor of decreased cell size | third instar larval stage phenotype of Scer\GAL4^Cg.PA, Tom40^JF02030

(Liu et al., 2018)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

porin^JF03251/Scer\GAL4^GMR.PFa is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PFa, Tom40^{UAS.Tag:FLAG,Tag:HA}

(Periasamy et al., 2022)

Suppressor of

Statement

Reference

porin^JF03251, Pisd^GMR.PZ, Scer\GAL4^GMR.long is a suppressor of eye photoreceptor cell | somatic clone | decreased number phenotype of Pect²⁹, Scer\FLP1^ey.PU

(Zhao and Wang, 2020)

porin^JF03251, Pisd^GMR.PZ, Scer\GAL4^GMR.long is a suppressor of rhabdomere | somatic clone | decreased number phenotype of Pect²⁹, Scer\FLP1^ey.PU

(Zhao and Wang, 2020)

NOT Suppressor of

Statement

Reference

porin^JF03251/Scer\GAL4^GMR.PFa is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PFa, Tom40^{UAS.Tag:FLAG,Tag:HA}

(Periasamy et al., 2022)

porin^JF03251/Scer\GAL4^Cg.PA is a non-suppressor of fat cell | early third instar larval stage phenotype of Scer\GAL4^Cg.PA, Tom40^JF02030

(Liu et al., 2018)

porin^JF03251/Scer\GAL4^Cg.PA is a non-suppressor of autophagosome | early third instar larval stage phenotype of Scer\GAL4^Cg.PA, Tom40^JF02030

(Liu et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

29572

y¹ v¹; P{TRiP.JF03251}attP2/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

porin^JF03251

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

Open Close

URL: https://flybase.org/reports/FBal0242427.html

⇱ FlyBase Allele Report: Dmel\porin[JF03251]

Report Sections