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⇱ FlyBase Gene Report: Dmel\mor

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FB2026_01 , released March 12, 2026
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General Information
Symbol
Dmel\mor
Species
D. melanogaster
Name
moira
Annotation Symbol
CG18740
Feature Type
FlyBase ID
FBgn0002783
Gene Model Status
Stock Availability
Gene Summary
moira (mor) encodes a member of the trithorax group of homeotic gene regulators. The product of mor is a chromatin remodeling protein and functions as the Swi3 component of the Brahma complex. [Date last reviewed: 2018-09-20] (FlyBase Gene Snapshot)
Also Known As

BAP155, Moi, brahma-associated protein 155

Genomic Location
Cytogenetic map
Sequence location
Recombination map
3-58
RefSeq locus
NT_033777 REGION:15968134..15972913
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
Gene Ontology (GO) Annotations (14 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:brm; FB:FBgn0000212
inferred from physical interaction with FLYBASE:z; FB:FBgn0004050
inferred from physical interaction with FLYBASE:Bap60; FB:FBgn0025463
inferred from physical interaction with FLYBASE:Bap111; FB:FBgn0030093
inferred from physical interaction with UniProtKB:Q9V464
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000301254
Biological Process (9 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:numb; FB:FBgn0002973
inferred from genetic interaction with FLYBASE:brat; FB:FBgn0010300
inferred from genetic interaction with FLYBASE:Rel; FB:FBgn0014018
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from sequence or structural similarity with MGI:MGI:1203524
inferred from sequence or structural similarity with MGI:MGI:1203524
inferred from biological aspect of ancestor with PANTHER:PTN000301254
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000301253
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
moira (mor) encodes a member of the trithorax group of homeotic gene regulators. The product of mor is a chromatin remodeling protein and functions as the Swi3 component of the Brahma complex. [Date last reviewed: 2018-09-20]
(Alliance, FBgn0002783 )
Gene Group (FlyBase)
BRAHMA ASSOCIATED PROTEINS COMPLEX -
The Brahma associated proteins (BAP) complex is an ATP-dependent chromatin remodeling complex. (Adapted from FBrf0192510.)
POLYBROMO-CONTAINING BRAHMA ASSOCIATED PROTEINS COMPLEX -
Brahma (BRM) complexes are ATP-dependent chromatin remodeling complexes. The Polybromo-containing Brahma associated proteins (PBAP) complex is distinguished by the presence of polybromo and Bap170 subunits. (Adapted from FBrf0192510.)
NON-CANONICAL BRAHMA ASSOCIATED PROTEINS COMPLEX -
Brahma (BRM) complexes are ATP-dependent chromatin remodeling complexes. The non-canonical BAP (ncBAP) complex is distinguished by the presence of a Bicra subunit. (Adapted from FBrf0247407.)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
mor: moira (J.A. Kennison)
Isolated as a dominant suppressor of the antenna-to-leg transformation in a Pc2 AntpNs double heterozygote. Strongly suppresses the antennal transformation in an AntpNs heterozygote, but does not suppress the antennal transformation in a strain containing a heat-shock driven Antennapedia cDNA. Also behaves as a dominant suppressor of Pc and Pcl mutations. All alleles associated with a common recessive embryonic lethality. Mitotic clones induced during larval growth lead to transformation of haltere tissue to wing tissue. Ubx130/mor has low frequency of haltere to wing transformation.
Summary (Interactive Fly)

Trithorax-complex protein - SWI3 homolog - chromatin remodeling protein - functions as the Swi3 component of the Brahma complex - GAF (Trithorax-like) and Moira interact directly with Yorkie

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\mor for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VF03)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.54

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0083238
3983
1209
FBtr0302550
3791
1145
Additional Transcript Data and Comments
Reported size (kB)

4.5 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
FBpp0082692
131.4
1209
5.47
FBpp0291706
124.8
1145
5.35
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

1189 (aa); 170 (kD observed)

Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mor using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.48

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

mor transcripts are detected by northern blot at 0-4hr of embryogenesis, reach a peak in 4-8hr embryos and decline until the 2nd instar larval stage. The are expressed also in third instar larvae, pupae, and adult males and females. mor transcripts are ubiquitously expressed in early embryos as assayed by in situ hybridization. They are enriched in the CNS, midgut and hindgut of older embryos.

Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

mor protein is ubiquitously expressed in early embryos. It is enriched in the CNS, midgut and hindgut of older embryos.

Marker for
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\mor in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
mor
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 21 )
For All Classical and Insertion Alleles Show
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of mor
Transgenic constructs containing regulatory region of mor
Aberrations (Deficiencies and Duplications) ( 25 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
macrochaeta & haltere | posterior | somatic clone
wing margin & macrochaeta | somatic clone
Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (3)
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (3)
Mus musculus (laboratory mouse) (3)
Xenopus tropicalis (Western clawed frog) (2)
Danio rerio (Zebrafish) (4)
Caenorhabditis elegans (Nematode, roundworm) (1)
11 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Arabidopsis thaliana (thale-cress) (4)
10 of 13
Yes
Yes
10 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
9 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
9 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:mor. Refer to their site for version information.
Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Potential Models Based on Orthology ( 1 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
12 of 14
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Interaction Browsers
Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
Interaction Browsers
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyBase
External Links
External Data
Linkouts
KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3R
Recombination map
3-58
Cytogenetic map
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
89A8-89A11
Limits computationally determined from genome sequence between P{PZ}blp01618 and P{PZ}gish04895&P{EP}EP3171
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
88E9-88F2
(determined by in situ hybridisation)
Location from complementation analysis with deficiency and duplication chromosomes (details unspecified).
Experimentally Determined Recombination Data
Left of (cM)
Right of (cM)
Notes

Based on 18 recombinants between jvl and Sbsbd-2.

Stocks and Reagents
Stocks (17)
Genomic Clones (18)
cDNA Clones (115)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
Antibody Information
Laboratory Generated Antibodies
Commercially Available Antibodies
Cell Line Information
Publicly Available Cell Lines
Other Stable Cell Lines
Other Comments

Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.

Pc, Scm, Psc, ph-p and ph-d contribute to the PRC1 (Polycomb repressive complex 1). PRC1 directly antagonizes ATP-dependent remodeling of nucleosomal arrays in a purified system and may directly modulate (and be modified by) SWI/SNF (brm/mor) activity.

mor is required for the function of multiple homeotic genes in most imaginal tissues.

Identified in a screen for modifiers of the Dfd13/Dfd3 mutant phenotype. Shows no interaction with the Pc mutant phenotype.

mor is an essential gene necessary for the transcriptional regulation of multiple homeotic and segmentation genes. Germline clonal analysis demonstrates that mor is important for proper oogenesis and somatic clonal analysis demonstrates that mor is required for the correct differentiation of imaginal structures in the adult cuticle.

mor is required for the function of other homeotic genes.

Sections of the Scr regulatory region may be important for regulation of Scr by Polycomb- and trithorax-group genes.

Mutations of mor interact with Dfd to reduce the viability of the Dfd3/Dfd13 combination.

Mutations cannot rescue the lethality of the Df(1)ph-2-Psc1 interaction, demonstrating that trx group mutations cannot suppress Pc group phenotypes.

Isolated as a dominant suppressor of the antenna-to-leg transformation in a Pc2 AntpNs double heterozygote. Strongly suppresses the antennal transformation in an AntpNs heterozygote, but does not suppress the antennal transformation in a strain containing a heat-shock driven Antp cDNA. Also behaves as a dominant suppressor of Pc and Pcl mutations. All alleles associated with a common recessive embryonic lethality. Mitotic clones induced during larval growth lead to transformation of haltere tissue to wing tissue. Ubx130/mor has low frequency of haltere to wing transformation.

mor is one of the 18 loci identified in a screen for dominant modifiers of Pc and/or Antp phenotypes. Alleles of Pc, Pcl, Scm, Dll, brm, kto, Scr and trx show clear dominant enhancement or suppression of AntpScx, whereas alleles of vtd, Vha55, Su(Pc)37D, urd, mor, skd and osa do not. Mosaic analysis with mutant alleles reveals homeotic transformations in adult cuticle.

Relationship to Other Genes
Source for database merge of

Source for merge of: mor BAP155

Source for merge of: mor CG4275

Additional comments

Source for merge of mor CG4275 was sequence comparison ( date:001104 ).

Nomenclature History
Source for database identify of
Nomenclature comments
Etymology

"Moira" means "fate" in Greek.

Synonyms and Secondary IDs (20)
Reported As
Symbol Synonym
CG4275
l(3)89B1
mor
(Isaacson et al., 2024, Heigwer et al., 2023, Yheskel et al., 2023, Molnar et al., 2022, Azpurua et al., 2021, Ordway et al., 2021, Shidlovskii et al., 2021, Jin et al., 2020, Overton et al., 2020, Chubak et al., 2019, Jiang et al., 2019, Shokri et al., 2019, Bischof et al., 2018, Dasari et al., 2018, Richardson and Portela, 2018, Song et al., 2017, Morimoto et al., 2016, Sarov et al., 2016, Baëza et al., 2015, Fischer et al., 2015, Nikalayevich and Ohkura, 2015, Richardson, 2015.3.11, Schertel et al., 2015, Zang et al., 2015, Eroglu et al., 2014, Gonzalez et al., 2014, Janssens et al., 2014, Toshima et al., 2014, Bengani et al., 2013, Kockmann et al., 2013, Kwon et al., 2013, Moshkin et al., 2013, Rougeot et al., 2013, Vasanthi et al., 2013, Antao et al., 2012, Hainaut et al., 2012, Curtis et al., 2011, Davis et al., 2011, Di Stefano et al., 2011, Friedman et al., 2011, Neumüller et al., 2011, Rodriguez-Jato et al., 2011, Arancio et al., 2010, Gan et al., 2010, Smulders-Srinivasan et al., 2010, Sing et al., 2009, Terriente-Félix and de Celis, 2009, Chalkley et al., 2008, Hauenschild et al., 2008, Nakamura et al., 2008, Petruk et al., 2008, Schmidt et al., 2008, Vázquez et al., 2008, Baeg et al., 2007, Chang et al., 2007, Dietzl et al., 2007, Slack et al., 2007, Xing et al., 2007, Molnar et al., 2006, Möller et al., 2005, Stevaux et al., 2005, Marenda et al., 2003, Hirose et al., 2001)
Name Synonyms
Bap155/Moira
brahma associated protein 155 kDa
brahma-associated protein 155
brahma-like
Secondary FlyBase IDs
  • FBgn0025464
  • FBgn0042208
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
Study result (0)
Result
Result Type
Title
External Crossreferences and Linkouts ( 61 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
FlyMine - An integrated database for Drosophila genomics
InterPro - A database of protein families, domains and functional sites
KEGG Genes - Molecular building blocks of life in the genomic space.
MARRVEL_MODEL - MARRVEL (model organism gene)
Linkouts
BioGRID - A database of protein and genetic interactions.
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
References (279)