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FB2026_01 , released March 12, 2026

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General Information

Symbol

Dmel\5-HT1A

Species

D. melanogaster

Name

5-hydroxytryptamine (serotonin) receptor 1A

Annotation Symbol

CG16720

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004168

Gene Model Status

Current

Stock Availability

189 publicly available

Gene Summary

5-hydroxytryptamine (serotonin) receptor 1A (5-HT1A) encodes a 5-hydroxytryptamine (serotonin) GPCR that belongs to the Class A GPCR family. They bind and transmit the signal from the neurotransmitter 5-HT (serotonin). The family can be subdivided into several subclasses based on pharmacology, signal transduction and structure. There are 5 genes encoding serotonin receptors in the Drosophila melanogaster genome: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT7. The product of 5-HT1A has been implicated in several aspects of adult behavior, including baseline sleep, aggression, courtship, as well as memory formation. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)

All Summaries

Also Known As

5HT1A, 5HT-dro2A, 5-HT1ADro, 5-HT_1A, 5-HT

Key Links

Genomic Location

Cytogenetic map

56B2-56B5

Sequence location

2R:19,067,155..19,121,958 [+]

Recombination map

2-88

RefSeq locus

NT_033778 REGION:19067155..19121958

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (18 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables G protein-coupled serotonin receptor activity

inferred from direct assay

(Gasque et al., 2013)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

enables G protein-coupled amine receptor activity

inferred from sequence or structural similarity

(Radford et al., 2002)

enables G protein-coupled receptor activity

inferred from electronic annotation with InterPro:IPR000276

(InterPro Project Members, 2004-)

enables G protein-coupled serotonin receptor activity

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

traceable author statement

(Tierney, 2001)

inferred from biological aspect of ancestor with PANTHER:PTN000664111

(GO Reference Genome Project, 2011-)

enables Gi/o-coupled serotonin receptor activity

non-traceable author statement

(Tierney, 2001)

enables neurotransmitter receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000664111

(GO Reference Genome Project, 2011-)

Biological Process (10 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway

inferred from direct assay

(Saudou et al., 1992)

involved_in anesthesia-resistant memory

inferred from direct assay

(Lee et al., 2011)

involved_in inter-male aggressive behavior

inferred from mutant phenotype

(Williams et al., 2014)

involved_in male courtship behavior

inferred from mutant phenotype

(Williams et al., 2014)

involved_in phospholipase C-activating serotonin receptor signaling pathway

inferred from direct assay

(Saudou et al., 1992)

involved_in regulation of circadian sleep/wake cycle, sleep

inferred from mutant phenotype

(Yuan et al., 2006)

involved_in serotonin receptor signaling pathway

inferred from direct assay

(Gasque et al., 2013)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway

traceable author statement

(Tierney, 2001)

inferred from biological aspect of ancestor with PANTHER:PTN002797960

(GO Reference Genome Project, 2011-)

involved_in chemical synaptic transmission

inferred from biological aspect of ancestor with PANTHER:PTN000664111

(GO Reference Genome Project, 2011-)

involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

inferred from biological aspect of ancestor with PANTHER:PTN000664111

(GO Reference Genome Project, 2011-)

involved_in G protein-coupled receptor signaling pathway

inferred from electronic annotation with InterPro:IPR000276

(InterPro Project Members, 2004-)

involved_in phospholipase C-activating serotonin receptor signaling pathway

traceable author statement

(Tierney, 2001)

involved_in serotonin receptor signaling pathway

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in dendrite

inferred from biological aspect of ancestor with PANTHER:PTN000664111

(GO Reference Genome Project, 2011-)

located_in membrane

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR017452

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000664111

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

5-HYDROXYTRYPTAMINE (SEROTONIN) GPCRs

Protein Family (UniProt)

Belongs to the G-protein coupled receptor 1 family. (P28285)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

5-HYDROXYTRYPTAMINE (SEROTONIN) GPCRs -: 5-hydroxytryptamine (serotonin) GPCRs belong to the Class A GPCR family. They bind and transmit the signal from the neurotransmitter 5-HT (serotonin). The family can be subdivided into seven subclasses: 5-HT1-7 based on pharmacology, signal transduction and structure. (Adapted from PMID:18571247).

Protein Function (UniProtKB)

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins which inhibit adenylate cyclase.

(UniProt, P28285)

Summary (Interactive Fly)

seven-pass transmembrane protein, 5-HT1A promotes baseline sleep, aggression, courtship and memory formation

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\5-HT1A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P28285)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Gene model reviewed during 5.50

Stop-codon suppression (UAG) postulated; FBrf0234051.

Gene model reviewed during 6.25

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

5-HT1A-RB

FBtr0086577

NM_166322

5019

834

5-HT1A-RC

FBtr0474126

NM_001369983

5019

846

Additional Transcript Data and Comments

Reported size (kB)

6.2 (northern blot)

(Saudou et al., 1992)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

5-HT1A-PB

FBpp0085761

89.6

834

5.65

FBpp0423127

91.0

846

6.35

AAF57603

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

834 (aa)

(Saudou et al., 1992)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P28285

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\5-HT1A using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

5-HT1A_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.65

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16 -- 17

larval VUM neuron

(Saudou et al., 1992)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

larval midline neuron

(Kearney et al., 2004)

embryonic stage 14

larval H-cell

(Stagg et al., 2011)

larval H-cell sib

(Stagg et al., 2011)

larval MP1 neuron

(Stagg et al., 2011)

embryonic stage 16 -- 17

presumptive embryonic/larval central nervous system

(Saudou et al., 1992)

ventral midline of embryo

(Saudou et al., 1992)

embryonic stage 17

larval MP1 neuron

(Wheeler et al., 2006)

larval H-cell

(Wheeler et al., 2006)

larval H-cell sib

(Wheeler et al., 2006)

Additional Descriptive Data

5-HT1A is expressed in the H-cell, H-cell sib and in two MP1 neurons.

(Stagg et al., 2011)

5-HT1B transcripts are detected throughout development with a peak in 16-24hr embryos. They are found in adult heads but not bodies. In embryos, expression starts in stage 16 and is restricted to the CNS. In each abdominal segment, 5-HT1B transcripts are expressed in a group of 6-8 cells located ventrally on the midline that are thought to be the VUM neurons. In thoracic segments, they are also expressed in lateral cells.

(Saudou et al., 1992)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain | restricted

(Lee et al., 2011)

mushroom body dorsal paired medial cell

(Lee et al., 2011)

serotonergic neuron | subset

(Lee et al., 2011)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

5-HT1A protein is expressed in a subset of serotonergic neurons of the adult brain, including the mushroom body dorsal paired medial neurons.

(Lee et al., 2011)

Marker for

serotonergic neuron

(Lee et al., 2011)

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{5-HT1A-GAL4.L}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

larval ventral nerve cord

(Luo et al., 2012)

adult stage

adult insulin secreting cell of pars intercerebralis

(Luo et al., 2012)

ellipsoid body

(Luo et al., 2012)

pars intercerebralis

(Luo et al., 2012)

late third instar larval stage

larval insulin secreting cell of pars intercerebralis

(Luo et al., 2012)

Reporter: TI{GAL4}5-HT1A^Gal4

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

alpha/beta Kenyon cell | subset

(Ries et al., 2017)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\5-HT1A in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\5-HT1A

View exonic expression by tissue for Dmel\5-HT1A

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004168

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37196/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004168

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004168

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004168

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG16720

Flygut - An atlas of the Drosophila adult midgut

FBgn0004168

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 21 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 14 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of 5-HT1A

Transgenic constructs containing regulatory region of 5-HT1A

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2R)Δ5kb

(Yuan et al., 2006)

Df(2R)Exel6068

(Ryder, 2004.4.26)

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Other Phenotypes

Allele

abnormal behavior

5-HT1A^Δ5kb

abnormal behavior | male limited, with Scer\GAL4^Ilp2.PR

5-HT1A^JF01852

abnormal cold stress response

5-HT1A^Δ5kb

abnormal cold stress response, with Scer\GAL4^Ilp2.215-3

abnormal cold stress response, with Scer\GAL4^Ilp2.PW

abnormal courtship behavior | male limited, with Scer\GAL4^Ilp2.PR

5-HT1A^JF01852

abnormal heat stress response

5-HT1A^Δ5kb

abnormal heat stress response, with Scer\GAL4^Ilp2.215-3

5-HT1A^KK108407

abnormal heat stress response, with Scer\GAL4^Ilp2.PW

5-HT1A^KK108407

abnormal locomotor behavior | adult stage, with Scer\GAL4^nSyb.PS

abnormal medium-term memory | adult stage, with Scer\GAL4^c739

5-HT1A^KK108407

abnormal memory, with Scer\GAL4^c739

5-HT1A^KK108407

abnormal memory, with Scer\GAL4^c739, Scer\GAL80^ts.αTub84B

5-HT1A^KK108407

abnormal memory, with Scer\GAL4^ey-OK107, Scer\GAL80^ts.αTub84B

5-HT1A^KK108407

abnormal sleep | adult stage

5-HT1A^attP

abnormal starvation stress response

5-HT1A^Δ5kb

abnormal starvation stress response, with Scer\GAL4^ey-OK107

abnormal starvation stress response, with Scer\GAL4^Ilp2.215-3

abnormal starvation stress response, with Scer\GAL4^Ilp2.PW

short lived

5-HT1A^Δ5kb

short lived, with Scer\GAL4^ey-OK107

short lived, with Scer\GAL4^Ilp2.215-3

short lived, with Scer\GAL4^Ilp2.PW

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (92)

Hsap\HTR1A 👁 Image

11 of 14

Yes

Hsap\HTR1B 👁 Image

4 of 14

Yes

Hsap\HTR1E 👁 Image

4 of 14

Yes

Hsap\HTR1F 👁 Image

4 of 14

Yes

Hsap\HTR1D 👁 Image

3 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\AVPR1B 👁 Image

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CXCR4 👁 Image

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\GPR52 👁 Image

1 of 14

Hsap\GPR101 👁 Image

1 of 14

Hsap\GPR161 👁 Image

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\PROKR1 👁 Image

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (25)

Rnor\Htr1a 👁 Image

12 of 14

Yes

Rnor\Htr1b 👁 Image

4 of 14

Yes

Rnor\Htr1d 👁 Image

4 of 14

Yes

Rnor\Htr1f 👁 Image

4 of 14

Yes

Rnor\Htr5a 👁 Image

2 of 14

Rnor\Htr5b 👁 Image

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (24)

Mmus\Htr1a 👁 Image

9 of 14

Yes

Mmus\Htr1b 👁 Image

5 of 14

Yes

Mmus\Htr1f 👁 Image

4 of 14

Yes

Mmus\Htr1d 👁 Image

3 of 14

Yes

Mmus\Htr5a 👁 Image

2 of 14

Mmus\Htr5b 👁 Image

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (67)

Xtro\htr1a 👁 Image

5 of 13

Yes

Xtro\htr1b 👁 Image

3 of 13

Yes

Xtro\htr1e 👁 Image

3 of 13

Yes

Xtro\htr1d 👁 Image

2 of 13

Yes

Xtro\htr1f 👁 Image

2 of 13

Yes

Xtro\htr5a 👁 Image

2 of 13

Xtro\ackr4 👁 Image

1 of 13

Yes

Xtro\adora1 👁 Image

1 of 13

Xtro\adora2a 👁 Image

1 of 13

Xtro\adora2b 👁 Image

1 of 13

Xtro\adora3.2 👁 Image

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\avpr2 👁 Image

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\gigyf2 👁 Image

1 of 13

Xtro\gpr65 👁 Image

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Xtro\LOC100488258 👁 Image

1 of 13

Xtro\LOC100489056 👁 Image

1 of 13

Xtro\LOC100490372 👁 Image

1 of 13

Xtro\LOC100491797 👁 Image

1 of 13

Xtro\LOC100496229 👁 Image

1 of 13

Yes

Xtro\LOC100498398 👁 Image

1 of 13

Yes

Xtro\LOC105946838 👁 Image

1 of 13

Xtro\LOC116411706 👁 Image

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\opn5 👁 Image

1 of 13

Xtro\opn8 👁 Image

1 of 13

Xtro\opnpl [provisonal]👁 Image

1 of 13

Xtro\p2ry4 👁 Image

1 of 13

Yes

Xtro\rho 👁 Image

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xtro\tmtops.2 👁 Image

1 of 13

Yes

Xtro\tmtops 👁 Image

1 of 13

Yes

Xtro\triqk 👁 Image

1 of 13

Yes

Xtro\uts2rl 👁 Image

1 of 13

Xtro\XB996286 👁 Image

1 of 13

Xtro\XB5959819 👁 Image

1 of 13

Yes

Danio rerio (Zebrafish) (76)

Drer\htr1aa 👁 Image

12 of 14

Yes

Drer\htr1ab 👁 Image

9 of 14

Yes

Drer\htr1b 👁 Image

3 of 14

Yes

Drer\htr1d 👁 Image

3 of 14

Yes

Drer\htr1fa 👁 Image

2 of 14

Yes

Drer\htr1fb 👁 Image

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\htr1e 👁 Image

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\LOC563567 👁 Image

1 of 14

Drer\LOC567498 👁 Image

1 of 14

Drer\LOC100330650 👁 Image

1 of 14

Drer\LOC100331077 👁 Image

1 of 14

Yes

Drer\LOC100334962 👁 Image

1 of 14

Drer\LOC101885642 👁 Image

1 of 14

Yes

Drer\or90a1 👁 Image

1 of 14

Yes

Drer\or90b1 👁 Image

1 of 14

Yes

Drer\or90b2 👁 Image

1 of 14

Yes

Drer\or90c1 👁 Image

1 of 14

Yes

Drer\or90d1 👁 Image

1 of 14

Yes

Drer\or90d2 👁 Image

1 of 14

Yes

Drer\or90d3 👁 Image

1 of 14

Yes

Drer\or90e2 👁 Image

1 of 14

Yes

Drer\or90h1 👁 Image

1 of 14

Yes

Drer\or90h3 👁 Image

1 of 14

Yes

Drer\or90h4 👁 Image

1 of 14

Yes

Drer\or90j1 👁 Image

1 of 14

Yes

Drer\or92a1 👁 Image

1 of 14

Yes

Drer\or92a2 👁 Image

1 of 14

Yes

Drer\or92a7 👁 Image

1 of 14

Yes

Drer\or93a1 👁 Image

1 of 14

Yes

Drer\or93a7 👁 Image

1 of 14

Yes

Drer\or137-5

1 of 14

Yes

Drer\or137-8 👁 Image

1 of 14

Yes

Drer\or137-9

1 of 14

Yes

Drer\parietopsin 👁 Image

1 of 14

Yes

Drer\taar13a 👁 Image

1 of 14

Drer\taar13d 👁 Image

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (26)

Cele\ser-4 👁 Image

11 of 14

Yes

4 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

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1 of 14

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Anopheles gambiae (African malaria mosquito) (44)

Agam\GPR5HT1A 👁 Image

10 of 12

Yes

Agam\GPR5HT1B 👁 Image

5 of 12

Yes

Agam\GPRTYR 👁 Image

3 of 12

Agam\GPR5HT7 👁 Image

2 of 12

Agam\GPRNNA20 👁 Image

2 of 12

Agam\AgaP_AGAP000606 👁 Image

1 of 12

Agam\AgaP_AGAP002229 👁 Image

1 of 12

Agam\AgaP_AGAP004122 👁 Image

1 of 12

Agam\AgaP_AGAP012982 👁 Image

1 of 12

Agam\AgaP_AGAP013324 👁 Image

1 of 12

Agam\GPR5HT2A 👁 Image

1 of 12

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Agam\GPRNNA15 👁 Image

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Yes

Agam\GPROPDR 👁 Image

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Agam\GPRTAK1 👁 Image

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Agam\GPRVPR1 👁 Image

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Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:5-HT1A. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (37)

9 of 13

5 of 13

5 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

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Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

model of vesicoureteral reflux

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

11 of 14

109760

vesicoureteral reflux

4 of 14

👁 View report for transgene in fly.

4 of 14

182132

4 of 14

182134

3 of 14

182133

👁 View report for transgene in fly.

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0004168

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Neuroactive ligand-receptor interaction

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2016)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-88

Cytogenetic map

56B2-56B5

Sequence location

2R:19,067,155..19,121,958 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

56B2-56B5

Limits computationally determined from genome sequence between P{lacW}prod^k08810 and P{PZ}ena⁰²⁰²⁹&P{lacW}cora^k08713

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

56A-56B

(determined by in situ hybridisation)

(Saudou et al., 1992)

Experimentally Determined Recombination Data

Location

2-88

(FlyBase, 2016)

2-93.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (189)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Korea

12107

P{VT019053-GAL4}attP2

12108

P{VT019060-GAL4}attP2

12109

P{VT019068-GAL4}attP2

12369

P{VT019059-GAL4}attP2

12370

P{VT019063-GAL4}attP2

12371

P{VT019067-GAL4}attP2

12634

P{VT019071-GAL4}attP2

13113

P{VT019055-GAL4}attP2

16720R-1

16720R-3

v330198

v106094

More stocks available...

Genomic Clones (48)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (2)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE57708

Other clones

FI21522

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004168

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004168

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Flies with reduced 5-HT1A in insulin-producing cells are less resistant to starvation and heat knockdown, and display delayed recovery from cold coma.

(Luo et al., 2012)

Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.

(Claridge-Chang et al., 2001)

5-HT1A receptor inhibits adenylate cyclase and activates phospholipase C. Expression starts in late embryos predominantly in midline motor neurones, suggesting a role in motor control. 5-HT1A and 5-HT1B have a common chromosomal location and high sequence homology suggesting they are the result of a recent duplication event.

(Saudou et al., 1992)

One of several known Drosophila serotonin receptor encoding genes. Presumed to be a recent duplication of 5-HT1B gene.

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: 5-HT1A CG16720

(Lai, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (31)

Reported As

Symbol Synonym

5-HT

(Pan et al., 2020, Tierney, 2020)

5-HT-1a

(Mazzotta et al., 2020)

5-HT-dro2A

(Tierney, 2001)

5-HT1A

(Pandi-Perumal et al., 2025, Shi et al., 2025, Tawa and Notterman, 2025, Cheng et al., 2024, Huang et al., 2024, Mallick et al., 2024, Vannelli et al., 2024, Corthals et al., 2023, Gowda et al., 2023, Ko et al., 2023, Li et al., 2023, Rosikon et al., 2023, Voutyraki et al., 2023, Bourouliti and Skoulakis, 2022, Cao et al., 2022, Ma et al., 2022, Palavicino-Maggio and Sengupta, 2022, Ratnaparkhi and Sudhakaran, 2022, Schlichting et al., 2022, Ahn et al., 2021, Jeong et al., 2021, Scaplen and Petruccelli, 2021, Semaniuk et al., 2021, Vogt et al., 2021, Ahmad et al., 2020, Cheng and Frye, 2020, Chvilicek et al., 2020, He et al., 2020, Nässel and Zandawala, 2020, Texada et al., 2020, Wilson et al., 2020, Alekseyenko et al., 2019, Harbison et al., 2019, Meltzer et al., 2019, Rao and Deng, 2019.10.23, Ly et al., 2018, Ugrankar et al., 2018, Wu et al., 2018, Choi et al., 2017, Crocker et al., 2016, Hong et al., 2016, Jungreis et al., 2016, Nässel and Vanden Broeck, 2016, Aradska et al., 2015, Gene Disruption Project members, 2015-, Gnerer et al., 2015, Singh et al., 2014, Williams et al., 2014, Gasque et al., 2013, Kwon et al., 2013, Nässel et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Stagg et al., 2011, Rodriguez Moncalvo and Campos, 2009, Riedl et al., 2007, Wheeler et al., 2006)

5-HT1ADro

(Curran and Chalasani, 2012, Johnson et al., 2009, Maroteaux, 1995.5.31)

5-HT1a

(Kaneko et al., 2017, Tomita et al., 2017)

5-HT_1A

(Luo et al., 2014, Luo et al., 2012, Johnson et al., 2011)

5-HT_1ADRO

(Luo et al., 2012)

5-HT_1ADro

(Tierney, 2001)

5-HT^1ADro

(Johnson et al., 2009)

5HT

(Jo et al., 2021)

5HT-1A

(Ries et al., 2017)

5HT-R2A

5HT-dro2A

(Tierney, 2001, Boschert et al., 1991, Boschert et al., 1991, Buchner, 1991)

5HT-drp_2A

(Hen, 1993)

5HT1A

(Qu et al., 2024, Bae et al., 2023, Bossen et al., 2023, Petsakou and Perrimon, 2023, Wu et al., 2023, Muria et al., 2021, Roy et al., 2020, Sun et al., 2020, Deng et al., 2019, Hoopfer, 2016, Lee et al., 2011, Dierick and Greenspan, 2007, Witz et al., 1991)

5HT1a

(Qian et al., 2017, Ro et al., 2016)

5HT_1ADro

(Kerr et al., 2004)

5htdro2a

(Feng et al., 1996)

5htr1a

(Metaxakis et al., 2023)

CG16720

(Mao et al., 2024, Meadows, 2017.1.11, Williams et al., 2014, Luo et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009.1.15, Hauser et al., 2006, Bryson-Richardson et al., 2004)

DRO2A

(Han et al., 1998)

Dm5-HT1A

(Qi et al., 2017)

Dm5-HT_1A

(Blenau et al., 2017)

Dm5HTdro2A

(Blenau and Baumann, 2001)

HT1A

(Liu et al., 2015)

d5-HT1A

(Mohammad et al., 2016, Yuan et al., 2006)

Name Synonyms

5-hydroxytryptamine (serotonin) receptor 1A

(Shafer, 2025)

Serotonin receptor 1A

Serotonin receptor 2A

serotonin-receptor-2A

(Boschert et al., 1991)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 39 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37196

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P28285

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P28285

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P28285

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004168

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37196/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004168

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004168

FlyMine - An integrated database for Drosophila genomics

FBgn0004168

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG16720

MARRVEL_MODEL - MARRVEL (model organism gene)

37196

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004168

DroID - A comprehensive database of gene and protein interactions.

FBgn0004168

DRSC - Results frm RNAi screens

FBgn0004168

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

5-HT1A_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004168

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0004168

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG16720

Flygut - An atlas of the Drosophila adult midgut

FBgn0004168

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0004168

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Neuroactive ligand-receptor interaction

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (176)

URL: https://flybase.org/reports/FBgn0004168.html

⇱ FlyBase Gene Report: Dmel\5-HT1A

The following external sites may use different assemblies or annotations than FlyBase.

-0.65

Report Sections