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dRet, DmHD-59
regulates dendrite patterning, adhesion and stability - rescues mitochondrial morphology and muscle degeneration of Pink1 mutants
Please see the JBrowse view of Dmel\Ret for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.52
4.8 (northern blot)
4.5 (northern blot)
1235 (aa)
1235, 46 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ret using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: 0-24 hr AEL
Comment: Transcript of 5000nt with stronger expression than 6500nt
Comment: Transcript of 5000nt with stronger expression than 6500nt
Comment: Transcript of 5000nt with stronger expression than 6500nt
Ret transcript is expressed in the three migrating stomatogastric nervous system precursor cell clusters from embryonic stage 13-15; expression is reduced at the end of SNS migration. Ret is also expressed at the ventral midline of the embryonic CNS, and in a few cells in the developing anterior midgut. At late embryonic stages, Ret transcript is expressed in some cells of the esophagael and proventricular ganglia, in the midgut, and at the CNS midline.
Ret transcript is expressed in small clusters of cells at the midline of the ventral neve cord segments. In third instar larva, expression is detected in a small cell cluster in the posterior ventral nerve cord.
Ret transcript is first observed at embryonic stage 8, localized to intensely-stained irregularly shaped patches in the yolk sac; these patches are interior to all three germ layers, and do not overlap with the amnioserosa. This pattern continues through embryonic stage 11, and rapidly disappers at stage 12, as the germband retracts and organogenesis begins. Ret transcript is expressed in the Malpighian tubule primordium at embryonic stage 12, but vanishes from that tissue by stage 13. Ret is also expressed in the stomatogastric nervous system and in midgut imaginal islands from stage 12 and in the peripheral nervous system of the head from embryonic stage 16, and in isolated cells in the ventral nerve cord from stage 12. In the third instar larval eye-antennal imaginal disc, expression is detected in the retinal cluster near the morphogenetic furrow, and in the ocellar region. During oogenesis, expression is detected in nurse cells, but not in mature oocytes.
Ret transcript is detected at low levels in embryonic stages, and at very low levels in larvae and pupae. Embryonic expression is first detected after cellularization, and is transient. Expression reappears in a subset of neuroblasts at embryonic stage 11, and disappears at germ band retraction. Starting at stage 13-14, three rows of cells in the ventral nerve cord express Ret transcript. Transient expression is detected at stage 13 in some PNS cells, and some ganglial cells.
Ret was generally absent from differentiated epithelial cells (enterocytes
and enteroendocrine cells), but was expressed by adult somatic intestinal stem cells (ISCs) and their postmitotic,
undifferentiated progeny, the enteroblasts.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Ret in JBrowse2-54
2-54.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Ret codes for a transmembrane protein most similar in sequence to a mammalian proto-oncogene ret. Ret mRNA is transcribed in very small amounts in the embryonic, larval and pupal stages. mRNA is transiently expressed in neuroblasts in early embryos and is detected in subpopulations of differentiating PNS and CNS cells in late embryos.
Source for merge of: Ret CG1061
Source for merge of: Ret CG14396
Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known.
