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⇱ FlyBase Gene Report: Dmel\Rab5

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FB2026_01 , released March 12, 2026
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General Information
Symbol
Dmel\Rab5
Species
D. melanogaster
Name
Rab5
Annotation Symbol
CG3664
Feature Type
FlyBase ID
FBgn0014010
Gene Model Status
Stock Availability
Gene Summary
Rab5 (Rab5) encodes a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering the activity of the product of Rab5 affects many receptor-mediated signaling pathways as well as epithelial polarity. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
Also Known As

DRab5, l(2)k08232, Rab-protein 5, DmRab5

Genomic Location
Cytogenetic map
Sequence location
Recombination map
2-6
RefSeq locus
NT_033779 REGION:2359142..2365273
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
Gene Ontology (GO) Annotations (50 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from physical interaction with FLYBASE:hook; FB:FBgn0001202
inferred from physical interaction with FLYBASE:Tbc1d15-17; FB:FBgn0031233
inferred from physical interaction with FLYBASE:CG6607; FB:FBgn0039204
inferred from physical interaction with FLYBASE:Rbsn-5; FB:FBgn0261064
inferred from physical interaction with UniProtKB:Q9W060
inferred from physical interaction with UniProtKB:Q24314
inferred from physical interaction with UniProtKB:Q9VR38
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables GTP binding
inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR005225
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
inferred from biological aspect of ancestor with PANTHER:PTN001292747
inferred from electronic annotation with InterPro:IPR001806
Biological Process (32 terms)
Terms Based on Experimental Evidence (29 terms)
CV Term
Evidence
References
involved_in axon extension
inferred from mutant phenotype
involved_in axonogenesis
inferred from mutant phenotype
involved_in cellularization
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
involved_in endocytosis
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
involved_in oogenesis
inferred from mutant phenotype
involved_in phagocytosis
inferred from expression pattern
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from high throughput mutant phenotype
inferred from genetic interaction with FLYBASE:Vps35; FB:FBgn0034708
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
involved_in endocytosis
inferred from biological aspect of ancestor with PANTHER:PTN000634658
inferred from biological aspect of ancestor with PANTHER:PTN001292747
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
traceable author statement
traceable author statement
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
Cellular Component (14 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
located_in axon terminus
inferred from direct assay
located_in cell cortex
inferred from direct assay
inferred from direct assay
colocalizes_with early endosome
inferred from direct assay
located_in endocytic patch
inferred from direct assay
inferred from direct assay
inferred from high throughput direct assay
located_in plasma membrane
inferred from high throughput direct assay
colocalizes_with presynaptic endosome
inferred from direct assay
located_in synapse
inferred from high throughput direct assay
located_in synaptic vesicle
inferred from direct assay
located_in terminal bouton
inferred from direct assay
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
is_active_in early endosome
inferred from biological aspect of ancestor with PANTHER:PTN000634601
located_in early endosome
non-traceable author statement
is_active_in endocytic vesicle
inferred from biological aspect of ancestor with PANTHER:PTN000634566
is_active_in endomembrane system
inferred from biological aspect of ancestor with PANTHER:PTN001292747
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000634601
located_in vesicle
inferred from sequence or structural similarity with FLYBASE:Rab11; FB:FBgn0015790
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the small GTPase superfamily. Rab family. (Q9V3I2)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
GTPase activity
RHEA 19669:
Summaries
Gene Snapshot
Rab5 (Rab5) encodes a monomeric GTPase that controls entry of endocytosed cargo into the early endosome and is required for vesicle re-uptake at the synapse. Altering the activity of the product of Rab5 affects many receptor-mediated signaling pathways as well as epithelial polarity. [Date last reviewed: 2019-03-14]
(Alliance, FBgn0014010 )
Gene Group (FlyBase)
RAB GTPASES -
The Rab family are members of the Ras superfamily of small GTPases. Rabs regulate vesicle trafficking including cargo selection, vesicle budding, transport, docking and targeting. They localize to different intracellular compartments directed by specific isoprenylation of C-terminal motifs. (Adapted from PMID:15731001).
Protein Function (UniProtKB)
Small monomeric GTPase which cycles between active GTP-bound and inactive GDP-bound states (Probable). In its active state, binds to a variety of effector proteins to regulate cellular responses such as intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (Probable). Involved in multiple pathways of endocytic transport (Probable). As a critical component of the endocytic trafficking machinery, involved in establishment of morphogen concentration gradients during pattern formation and organogenesis, for example of the TGF-beta homolog dpp/decapentaplegic (PubMed:11136982). Involved in the development and function of the nervous system (PubMed:12743108). Maintains the integrity of endosomes during embryonic development (PubMed:12743108). May be involved in vesicle fusion and budding during synaptic vesicle recycling (PubMed:12743108). Maintains synaptic vesicle size uniformity (important for allowing quantitative release of neurotransmitters), probably by preventing homotypic vesicle fusion (PubMed:12876219). Involved in endosomal trafficking during Ca(2+)-triggered exocytosis at the presynaptic terminal (PubMed:12743108). During oogenesis involved in clathrin-mediated endocytic uptake of yolk proteins and their storage (PubMed:19050045). Required for maturation of early endosomal precursors into mature yolk granules (PubMed:19050045). Associates with endosomal membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns[4,5]P(2)) and mediates its removal (PubMed:19050045). PtdIns[4,5]P(2) removal contributes to endosomal maturation by affecting the ability of PtdIns[4,5]P(2)-binding components of the early endocytic machinery, including factors involved in clathrin recruitment and actin polymerisation, to remain associated (PubMed:19050045). Functions upstream of Rab7 in endolysosomal vesicle maturation but not in autolysosomal vesicle maturation (PubMed:27559127). Involved in trafficking and turnover of lysosomal proteins (PubMed:27559127). Stimulates the Rab7 guanyl-nucleotide exchange activity of the Mon1-Ccz1 complex, possibly by recruiting the Mon1-Ccz1 complex to vesicle membranes and enhancing its subsequent recruitment of Rab7 (PubMed:32391792). Involved in wing imaginal disc development (PubMed:35594316).
(UniProt, Q9V3I2)
Summary (Interactive Fly)

Rab family GTPase - required for fusion of endocytic vesicles with endosomes - required for endocytosis of vesicles at the synapse - required for tracheal maturation - regulates JAK/STAT activity, functions in endosomal transport to promotes wingless signaling - promotes F-actin reorganization in oogenesis

Gene Model and Products
Number of Transcripts
9
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Rab5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9V3I2)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.44

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.45

Gene model reviewed during 5.56

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0077798
1765
219
FBtr0077793
1871
219
FBtr0077796
2491
219
FBtr0077795
1739
219
FBtr0077797
2182
219
FBtr0077794
1719
219
FBtr0330668
1785
219
FBtr0330669
1772
219
FBtr0330670
1775
219
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
FBpp0077475
24.0
219
8.60
FBpp0077470
24.0
219
8.60
FBpp0077473
24.0
219
8.60
FBpp0077472
24.0
219
8.60
FBpp0077474
24.0
219
8.60
FBpp0077471
24.0
219
8.60
FBpp0303518
24.0
219
8.60
FBpp0303519
24.0
219
8.60
FBpp0303520
24.0
219
8.60
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rab5 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.05

Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Evidence
References
located_in axon terminus
inferred from direct assay
located_in cell cortex
inferred from direct assay
inferred from direct assay
colocalizes_with early endosome
inferred from direct assay
located_in endocytic patch
inferred from direct assay
inferred from direct assay
inferred from high throughput direct assay
located_in plasma membrane
inferred from high throughput direct assay
colocalizes_with presynaptic endosome
inferred from direct assay
located_in synapse
inferred from high throughput direct assay
located_in synaptic vesicle
inferred from direct assay
located_in terminal bouton
inferred from direct assay
Expression Deduced from Reporters
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Rab5 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
Rab5
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 25 )
For All Classical and Insertion Alleles Show
Other relevant insertions
Transgenic Constructs ( 49 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Rab5
Transgenic constructs containing regulatory region of Rab5
Aberrations (Deficiencies and Duplications) ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
egg chamber & basement membrane | apical, with Scer\GAL4slbo.2.6
endosome & embryonic nervous system
mitosis & nuclear chromosome
nerve terminal & synaptic vesicle, with Scer\GAL4hs.PS
nerve terminal & synaptic vesicle, with Scer\GAL4ninaE.PHS
photoreceptor cell & synaptic vesicle, with Scer\GAL4hs.PS
synaptic vesicle & larval neuromuscular junction
synaptic vesicle & larval neuromuscular junction, with Scer\GAL4elav-C155
Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (81)
12 of 14
Yes
Yes
1  
10 of 14
No
Yes
1  
2 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
3  
1 of 14
No
No
2  
1 of 14
No
No
1  
1 of 14
No
No
5  
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
3  
1 of 14
No
No
3  
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
1  
1 of 14
No
No
2  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (47)
12 of 14
Yes
Yes
Mus musculus (laboratory mouse) (45)
12 of 14
Yes
Yes
1 of 14
No
No
1  
Xenopus tropicalis (Western clawed frog) (43)
Danio rerio (Zebrafish) (58)
12 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (38)
12 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (31)
Arabidopsis thaliana (thale-cress) (63)
11 of 13
Yes
Yes
11 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (19)
Schizosaccharomyces pombe (Fission yeast) (8)
9 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Rab5. Refer to their site for version information.
Paralogs
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 5 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 13 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
11 of 14
4 of 14
3 of 14
3 of 14
3 of 14
3 of 14
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Interaction Browsers
Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
Interaction Browsers
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyBase
External Links
Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
External Data
Linkouts
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2L
Recombination map
2-6
Cytogenetic map
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
22E1-22E1
Limits computationally determined from genome sequence between P{lacW}s4989 and P{lacW}Rab5k08232
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
22E1-22F1
22E1-22E2
(determined by in situ hybridisation)
22E-22F
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (41)
Genomic Clones (20)
cDNA Clones (296)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
Other clones
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
Antibody Information
Laboratory Generated Antibodies
Commercially Available Antibodies
Cell Line Information
Publicly Available Cell Lines
Other Stable Cell Lines
Other Comments

An increase in the proportion of binucleated cells is seen following transfection of S2 cells with dsRNA made from templates generated with primers directed against this gene.

dsRNA has been made from templates generated with primers directed against this gene.

Transfection of S2 cells with dsRNA made from templates generated with primers directed against Rab5 profoundly inhibits the wg-signaling pathway.

dsRNA made from templates generated with primers directed against Rab5 that is transfected into S2 treated with Listeria monocytogenes reveals Rab5 to be involved in Listeria monocytogenes entry and vacuolar escape.

Rab5 is necessary for the formation of an apical cap, made of basement membrane components, over the surface of the anterior polar cells in stage 8 egg chambers.

Identified in an RNAi screen for host factors that alter infection of SL2 cells by M.fortuitum.

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.

Identification: Sequence similarity to Rab3.

Relationship to Other Genes
Source for database merge of

Source for merge of: Rab5 l(2)k08232

Additional comments
Nomenclature History
Source for database identify of
Nomenclature comments
Etymology
Synonyms and Secondary IDs (18)
Reported As
Symbol Synonym
AAF51265
BAA88244
Dm Rab5
Rab5
(Gbadamosi et al., 2025, Li et al., 2025, Li et al., 2025, Luo et al., 2025, McDonald et al., 2025, Moser et al., 2025, Tang et al., 2025, Tsakiri et al., 2025, Zhu et al., 2025, Collins et al., 2024, Dong et al., 2024, Kim et al., 2024, Miao et al., 2024, Nan et al., 2024, Puli et al., 2024, Sachan et al., 2024, Shweta et al., 2024, Szypulski et al., 2024, Vonolfen et al., 2024, Wilkin et al., 2024, Yu et al., 2024, Yuswan et al., 2024, Zhang et al., 2024, Bonello et al., 2023, Hossain et al., 2023, Joshi et al., 2023, Khalili et al., 2023, Kim et al., 2023, Koehler and Huber, 2023, Li et al., 2023, Maruzs et al., 2023, Mitchell et al., 2023, Nakayama et al., 2023, Pradhan et al., 2023, Saha et al., 2023, Scholl et al., 2023, Tsarouhas et al., 2023, Zhang et al., 2023, Zheng et al., 2023, Zhou et al., 2023, Zhou et al., 2023, Zhuang et al., 2023, Chaudhry et al., 2022, Chen and He, 2022, Enomoto and Igaki, 2022, Gonçalves Antunes et al., 2022, González-Ramírez et al., 2022, Hodgson et al., 2022, Lang et al., 2022, Lauzier et al., 2022, Meyer et al., 2022, Miao et al., 2022, Milosavljevic et al., 2022, Murakawa et al., 2022, National Institute of Genetics Fly Stocks, 2022-, Papagiannouli, 2022, Peterson et al., 2022, Rai and Kumar Roy, 2022, Sanchez-Lopez et al., 2022, Schnute et al., 2022, Sebastian et al., 2022, Simões et al., 2022, Tanasic et al., 2022, van de Leemput et al., 2022, Wang et al., 2022, Yang and Zhang, 2022, Alhadyian et al., 2021, Allen et al., 2021, Atienza-Manuel et al., 2021, Bernard et al., 2021, Boumard and Bardin, 2021, Chan et al., 2021, Cong et al., 2021, Evans et al., 2021, Furusawa and Emoto, 2021, Gong et al., 2021, Gore et al., 2021, Hounjet and Vooijs, 2021, Juarez-Carreño et al., 2021, Kawamura et al., 2021, Lattao et al., 2021, Lo Iacono et al., 2021, Lund et al., 2021, Ma and Brill, 2021, Martin et al., 2021, Martinez-Arroyo et al., 2021, Neuman et al., 2021, Petrignani et al., 2021, Rigon et al., 2021, Rimal et al., 2021, Sciambra 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et al., 2003)
rab5
(Scopelliti et al., 2025, Sharma and Chaudhary, 2024, Gao et al., 2022, Hu et al., 2022, Morata, 2021, Mysh and Poulton, 2021, Cai et al., 2019, Lőrincz et al., 2019, Scholz et al., 2019, Tsarouhas et al., 2019, Ma et al., 2018, Das and Cagan, 2017, Lammers et al., 2017, Norman et al., 2016, Romani et al., 2016, Xu and Wang, 2016, Chance and Bashaw, 2015, Enomoto et al., 2015, Liu et al., 2015, Sherrard and Fehon, 2015, Jagut et al., 2013, Lee et al., 2013, van den Brink et al., 2013, Cook et al., 2012, Fletcher et al., 2012, Jin et al., 2012, Troost et al., 2012, Chan et al., 2011, Parra-Peralbo and Culi, 2011, Tanaka et al., 2011, Assaker et al., 2010, Rhiner et al., 2010, Silies and Klämbt, 2010, Compagnon et al., 2009, Gilbert et al., 2009, Olswang-Kutz et al., 2009, Cuttell et al., 2008, Morrison et al., 2008, O'Connor-Giles et al., 2008, Devergne et al., 2007, Menut et al., 2007, Tountas and Fortini, 2007, Tsarouhas et al., 2007, Walthall et al., 2007, Jaekel and Klein, 2006, Solecki et al., 2006, Tsarouhas et al., 2006, DasGupta et al., 2005, Lu and Bilder, 2005, Okajima, 2005, Pelissier et al., 2003, Bellen, 2000.12.25)
Name Synonyms
Secondary FlyBase IDs
  • FBgn0022048
Datasets (1)
Study focus (1)
Experimental Role
Project
Project Type
Title
  • bait_protein
Interaction map generated by purification of most Rab factors, with identification of copurifying effectors by mass spectrometry.
Study result (0)
Result
Result Type
Title
External Crossreferences and Linkouts ( 93 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
Other crossreferences
AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
FlyMine - An integrated database for Drosophila genomics
InterPro - A database of protein families, domains and functional sites
KEGG Genes - Molecular building blocks of life in the genomic space.
MARRVEL_MODEL - MARRVEL (model organism gene)
Linkouts
BioGRID - A database of protein and genetic interactions.
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
References (737)