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⇱ FlyBase Gene Report: Dmel\mir-14

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FB2026_01 , released March 12, 2026
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General Information
Symbol
Dmel\mir-14
Species
D. melanogaster
Name
mir-14 stem loop
Annotation Symbol
CR43013
Feature Type
FlyBase ID
FBgn0262447
Gene Model Status
Stock Availability
Gene Summary
a cell death suppressor - regulates fat metabolism - regulates insulin production and metabolism through its target, sugarbabe (Interactive Fly, mir-14 )
Contribute a Gene Snapshot for this gene.
Also Known As

dme-miR-14, l(2)k10213, mir14

Genomic Location
Cytogenetic map
Sequence location
Recombination map
2-61
RefSeq locus
NT_033778 REGION:9553762..9553824
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Biological Process (12 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from electronic annotation with Rfam:RF00752
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of RISC complex
inferred from electronic annotation with Rfam:RF00752
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
-
Summaries
(Alliance, FBgn0262447 )
Pathway (FlyBase)
NEGATIVE REGULATORS OF HEDGEHOG SIGNALING PATHWAY -
Negative regulators of hedgehog signaling down-regulate the pathway, resulting in the repression of transcription of hh-responsive genes.
Summary (Interactive Fly)

a cell death suppressor - regulates fat metabolism - regulates insulin production and metabolism through its target, sugarbabe

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
0

Please see the JBrowse view of Dmel\mir-14 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Locations and structures of miRNA models as mapped by miRBase (FBrf0220601).

Conserved: found throughout the Drosophila genus (FBrf0230987).

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
FBtr0304459
22
FBtr0472715
22
FBtr0304458
63
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
miRBase - A searchable database of published miRNA sequences and annotation.
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mir-14 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Northern analysis of 24 microRNAs showed that a number of them were expressed constituitively throughout development.

Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\mir-14 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
mir-14
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of mir-14
Transgenic constructs containing regulatory region of mir-14
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (0)
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (0)
Mus musculus (laboratory mouse) (0)
Xenopus tropicalis (Western clawed frog) (0)
Danio rerio (Zebrafish) (0)
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (0)
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:mir-14. Refer to their site for version information.
Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Summary of Genetic Interactions
Interaction Browsers
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyBase
External Links
External Data
Linkouts
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2R
Recombination map
2-61
Cytogenetic map
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
45F1-45F1
Limits computationally determined from genome sequence between P{EP}EP2165&P{lacW}l(2)k01301k01301 and P{lacW}l(2)k09501k09501
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
45F1-45F2
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (8)
Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi and Array Information
Linkouts
Antibody Information
Laboratory Generated Antibodies
Commercially Available Antibodies
Cell Line Information
Publicly Available Cell Lines
Other Stable Cell Lines
Other Comments

mir-14 may be a dose dependant regulator of triacylglycerol and diacylglycerol and suppresses cell death.

New annotation (CR33010) in release 3 of the genome annotation.

Relationship to Other Genes
Source for database merge of
Additional comments

The annotation for mir-14 has been changed in release 5.31 of the genome annotation, so that instead of representing a mature miRNA it now represents the precursor stem loop pre-miRNA. The symbol of the annotation has been changed from CR33010 to CR43013 to reflect this change.

Nomenclature History
Source for database identify of
Nomenclature comments
Etymology
Synonyms and Secondary IDs (15)
Reported As
Symbol Synonym
miR-14
(Bernard et al., 2024, Jang et al., 2024, Chan et al., 2023, Yang et al., 2023, Li et al., 2022, Galagali and Kim, 2020, Jin et al., 2020, Kitatani et al., 2020, McNeill et al., 2020, Soleimani et al., 2020, Song and Zhou, 2020, Toprak et al., 2020, Xia et al., 2020, Xu et al., 2020, Reichholf et al., 2019, Le et al., 2018, Mondal et al., 2018, Ueda et al., 2018, Atilano et al., 2017, Church et al., 2017, Mendoza-Viveros et al., 2017, Mondal et al., 2017, Picao-Osorio et al., 2017, Nässel and Vanden Broeck, 2016, Yang et al., 2016, Fulga et al., 2015, Mugat et al., 2015, Nässel et al., 2015, Sanchez-Díaz et al., 2015, Suh et al., 2015, Kim et al., 2014, Nelson et al., 2014, Esslinger et al., 2013, Kannan and Fridell, 2013, Lucas and Raikhel, 2013, Nesler et al., 2013, Pancratov et al., 2013, Yamanaka et al., 2013, Chandrasekhar et al., 2012, Liu et al., 2012, Pushpavalli et al., 2012, Tan et al., 2012, Behura et al., 2011, Liu et al., 2011, Seitz et al., 2011, Smibert et al., 2011, Gehrke et al., 2010, Ghildiyal et al., 2010, Thomsen et al., 2010, Varghese et al., 2010, Czech et al., 2009, Kadener et al., 2009, Kadener et al., 2009, Ibáñez-Ventoso et al., 2008, Varghese and Cohen, 2007, Rehwinkel et al., 2006, Alvarez-Garcia and Miska, 2005, Leaman, 2005, Miska, 2005, Stark et al., 2005, Wienholds and Plasterk, 2005, Bartel, 2004, He and Hannon, 2004, Lai et al., 2003, Nelson et al., 2003, Sempere et al., 2003, Stark et al., 2003, Stark et al., 2003, Lagos-Quintana et al., 2001, Lee et al., 2001)
Name Synonyms
mir-14
mir-14 stem loop
Secondary FlyBase IDs
  • FBgn0046827
  • FBgn0021957
  • FBgn0262306
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
Study result (0)
Result
Result Type
Title
External Crossreferences and Linkouts ( 18 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
RNAcentral - A comprehensive ncRNA sequence collection representing all ncRNA types from a broad range of organisms
Other crossreferences
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
KEGG Genes - Molecular building blocks of life in the genomic space.
MARRVEL_MODEL - MARRVEL (model organism gene)
miRBase - A searchable database of published miRNA sequences and annotation.
Linkouts
DroID - A comprehensive database of gene and protein interactions.
FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
MIST (genetic) - An integrated Molecular Interaction Database
References (160)