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| Diskoidin domen receptor familija, izoforma 1 | |||
|---|---|---|---|
| Identifikatori | |||
| Simboli | DDR1; CAK; CD167; DDR; EDDR1; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE | ||
| Vanjski ID | OMIM: 600408 MGI: 99216 HomoloGene: 68212 GeneCards: DDR1 Gene | ||
| Pregled RNK izražavanja | |||
| 👁 Image | |||
| 👁 Image | |||
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| podaci | |||
| Ortolozi | |||
| Vrsta | Čovek | Miš | |
| Entrez | 780 | 12305 | |
| Ensembl | ENSG00000137332 | ENSMUSG00000003534 | |
| UniProt | Q08345 | O35407 | |
| RefSeq (mRNA) | NM_001954 | NM_007584 | |
| RefSeq (protein) | NP_001945 | NP_031610 | |
| Lokacija (UCSC) | Chr c6_COX: 30.99 - 31.01 Mb | Chr 17: 35.29 - 35.31 Mb | |
| PubMed pretraga | [1] | [2] | |
DDR1, ili CD167a (klaster diferencijacije 167a), je ljudski gen[1] koji je pripadnik broj 1 familije receptora s diskoidinskim domenom.
Receptorske tirozinske kinaze (RTK) igraju ključnu ulogu u komunikaciji ćelija sa njihovim mikro okruženjem. Ti molekuli su uključeni u regulaciju ćelijskog rasta, diferencijacije i metabolizma. Protein kodiran ovim genom je RTK koji je široko izražen u normalnim i transformisanim epitelnim ćelijama, i koji je aktiviran kolagenom. Ovaj protein pripada potfamiliji receptora tirozin kinaza koje sadrže homologni region sa Dictyostelium discoideum proteinom diskoidin I u njihovom ekstracelularnom domenu. Njegova auto-fosforilacija se postiže svim do sada testiranim kolagenima (tip I - VI). In situ studije i Northern-blot analiza su pokazale da je izražavanje ovog protein ograničeno na epitelske ćelije, posebno u bubrezima, plućima, gastrointestinalnom traktu, i mozgu. Dodatno, ovaj protein je značajno preizražen i u nekoliko ljudskih tumora iz dojki, jajnika, jednjaka, pedijatrijskog mozga. Ovaj gen se nalazi na hromozomu 6p21.3 u blizini nekoliko HLA klasa I gena. Alternativno splajsovanje (engleski: splicing) ovog gena proizvodi nekoliko transkriptnih varijanti.[1]
- Edelhoff S, Sweetser DA, Disteche CM (1995). „Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C.”. Genomics 25 (1): 309–11. DOI:10.1016/0888-7543(95)80144-B. PMID 7774938.
- Shelling AN, Butler R, Jones T, et al. (1995). „Localization of an epithelial-specific receptor kinase (EDDR1) to chromosome 6q16.”. Genomics 25 (2): 584–7. DOI:10.1016/0888-7543(95)80065-T. PMID 7789998.
- Weiner TM, Liu ET, Craven RJ, Cance WG (1995). „Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors.”. Ann. Surg. Oncol. 1 (1): 18–27. DOI:10.1007/BF02303537. PMID 7834423.
- Laval S, Butler R, Shelling AN, et al. (1995). „Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line.”. Cell Growth Differ. 5 (11): 1173–83. PMID 7848919.
- Kato JY, Matsuoka M, Strom DK, Sherr CJ (1994). „Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase.”. Mol. Cell. Biol. 14 (4): 2713–21. PMID 8139570.
- Di Marco E, Cutuli N, Guerra L, et al. (1993). „Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues.”. J. Biol. Chem. 268 (32): 24290–5. PMID 8226977.
- Perez JL, Shen X, Finkernagel S, et al. (1994). „Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain.”. Oncogene 9 (1): 211–9. PMID 8302582.
- Johnson JD, Edman JC, Rutter WJ (1993). „A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain.”. Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5677–81. DOI:10.1073/pnas.90.12.5677. PMID 8390675.
- Perez JL, Jing SQ, Wong TW (1996). „Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines.”. Oncogene 12 (7): 1469–77. PMID 8622863.
- Valent A, Meddeb M, Danglot G, et al. (1996). „Assignment of the NTRK4 (trkE) gene to chromosome 6p21.”. Hum. Genet. 98 (1): 12–5. DOI:10.1007/s004390050152. PMID 8682498.
- Playford MP, Butler RJ, Wang XC, et al. (1996). „The genomic structure of discoidin receptor tyrosine kinase.”. Genome Res. 6 (7): 620–7. DOI:10.1101/gr.6.7.620. PMID 8796349.
- Sakuma S, Saya H, Tada M, et al. (1997). „Receptor protein tyrosine kinase DDR is up-regulated by p53 protein.”. FEBS Lett. 398 (2-3): 165–9. DOI:10.1016/S0014-5793(96)01234-3. PMID 8977099.
- Nemoto T, Ohashi K, Akashi T, et al. (1998). „Overexpression of protein tyrosine kinases in human esophageal cancer.”. Pathobiology 65 (4): 195–203. DOI:10.1159/000164123. PMID 9396043.
- Tanaka K, Nagayama Y, Nakano T, et al. (1998). „Expression profile of receptor-type protein tyrosine kinase genes in the human thyroid.”. Endocrinology 139 (3): 852–8. DOI:10.1210/en.139.3.852. PMID 9492013.
- Vogel W, Gish GD, Alves F, Pawson T (1998). „The discoidin domain receptor tyrosine kinases are activated by collagen.”. Mol. Cell 1 (1): 13–23. DOI:10.1016/S1097-2765(00)80003-9. PMID 9659899.
- Shrivastava A, Radziejewski C, Campbell E, et al. (1998). „An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors.”. Mol. Cell 1 (1): 25–34. DOI:10.1016/S1097-2765(00)80004-0. PMID 9659900.
- Vogel W, Brakebusch C, Fässler R, et al. (2000). „Discoidin domain receptor 1 is activated independently of beta(1) integrin.”. J. Biol. Chem. 275 (8): 5779–84. DOI:10.1074/jbc.275.8.5779. PMID 10681566.
- Foehr ED, Tatavos A, Tanabe E, et al. (2000). „Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors.”. FASEB J. 14 (7): 973–81. PMID 10783152.
- Weiner HL, Huang H, Zagzag D, et al. (2001). „Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumors.”. Neurosurgery 47 (6): 1400–9. DOI:10.1097/00006123-200012000-00028. PMID 11126911.
- Mohan RR, Mohan RR, Wilson SE (2001). „Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase receptors in the cornea.”. Exp. Eye Res. 72 (1): 87–92. DOI:10.1006/exer.2000.0932. PMID 11133186.