(Preusmjereno sa stranice NTRK2)
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| Neurotrofna tirozinska kinaza, receptor, tip 2 | |||||||||||
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| 👁 Image PDB prikaz baziran na 1hcf. | |||||||||||
| Dostupne strukture | |||||||||||
| 1HCF, 1WWB, 2MFQ, 4ASZ, 4AT3, 4AT4, 4AT5 | |||||||||||
| Identifikatori | |||||||||||
| Simboli | NTRK2; GP145-TrkB; TRKB; trk-B | ||||||||||
| Vanjski ID | OMIM: 600456 MGI: 97384 HomoloGene: 4504 GeneCards: NTRK2 Gene | ||||||||||
| EC broj | 2.7.10.1 | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
| 👁 Image | |||||||||||
| 👁 Image | |||||||||||
| 👁 Image | |||||||||||
| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 4915 | 18212 | |||||||||
| Ensembl | ENSG00000148053 | ENSMUSG00000055254 | |||||||||
| UniProt | Q16620 | P15209 | |||||||||
| Ref. Sekv. (iRNK) | NM_001007097 | NM_001025074 | |||||||||
| Ref. Sekv. (protein) | NP_001007098 | NP_001020245 | |||||||||
| Lokacija (UCSC) | Chr 9: 87.28 - 87.64 Mb | Chr 13: 58.81 - 59.13 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
TrkB receptor (TrkB tirozinska kinaza, receptor BDNF/NT-3 faktora rasta, receptorska neurotrofna tirozinska kinaza, tip 2) protein je koji je kod ljudi kodiran NTRK2 genom.[1]
TrkB formira interakcije sa:
- moždani neurotrofni faktor (BDNF),[2][3]
- FYN,[4]
- NCK2,[5]
- PLCG1,[5][6]
- Seveestosom 1,[7] and
- SHC3.[5][8]
- Moždani neurotrofni faktor (BDNF)
- Neurotrofin-3 (NT-3)
- Neurotrofin-4 (NT-4)
- N-Acetilserotonin
- HIOC
- Amitriptilin[9]
- 7,8-Dihidroksiflavon
- 7,8,3'-Trihidroksiflavon
- 4'-Dimetilamino-7,8-dihidroksiflavon[10]
- Deoksigedunin[11]
- LM-22A4
- ↑ Nakagawara A, Liu XG, Ikegaki N, White PS, Yamashiro DJ, Nycum LM, Biegel JA, Brodeur GM (January 1995). „Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2)”. Genomics 25 (2): 538–46. DOI:10.1016/0888-7543(95)80055-Q. PMID 7789988.
- ↑ Haniu M, Montestruque S, Bures EJ, Talvenheimo J, Toso R, Lewis-Sandy S, Welcher AA, Rohde MF (October 1997). „Interactions between brain-derived neurotrophic factor and the TRKB receptor. Identification of two ligand binding domains in soluble TRKB by affinity separation and chemical cross-linking”. J. Biol. Chem. 272 (40): 25296–303. DOI:10.1074/jbc.272.40.25296. PMID 9312147.
- ↑ Naylor RL, Robertson AG, Allen SJ, Sessions RB, Clarke AR, Mason GG, Burston JJ, Tyler SJ, Wilcock GK, Dawbarn D (March 2002). „A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4”. Biochem. Biophys. Res. Commun. 291 (3): 501–7. DOI:10.1006/bbrc.2002.6468. PMID 11855816.
- ↑ Iwasaki Y, Gay B, Wada K, Koizumi S (July 1998). „Association of the Src family tyrosine kinase Fyn with TrkB”. J. Neurochem. 71 (1): 106–11. DOI:10.1046/j.1471-4159.1998.71010106.x. PMID 9648856.
- ↑ 5,0 5,1 5,2 Suzuki S, Mizutani M, Suzuki K, Yamada M, Kojima M, Hatanaka H, Koizumi S (June 2002). „Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor”. Biochem. Biophys. Res. Commun. 294 (5): 1087–92. DOI:10.1016/S0006-291X(02)00606-X. PMID 12074588.
- ↑ Meakin SO, MacDonald JI, Gryz EA, Kubu CJ, Verdi JM (April 1999). „The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation”. J. Biol. Chem. 274 (14): 9861–70. DOI:10.1074/jbc.274.14.9861. PMID 10092678.
- ↑ Geetha T, Wooten MW (February 2003). „Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling”. J. Biol. Chem. 278 (7): 4730–9. DOI:10.1074/jbc.M208468200. PMID 12471037.
- ↑ Nakamura T, Muraoka S, Sanokawa R, Mori N (March 1998). „N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling”. J. Biol. Chem. 273 (12): 6960–7. DOI:10.1074/jbc.273.12.6960. PMID 9507002.
- ↑ PMID 19549602
- ↑ Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, Phun LH, France S, Xiao G, Jia Y, Luo HR, Ye K (November 2010). „A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect”. J Med Chem 53: 8274. DOI:10.1021/jm101206p. PMID 21073191.
- ↑ {{Cite http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011528 }}
- Klein R, Conway D, Parada LF, Barbacid M (May 1990). „The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain”. Cell 61 (4): 647–56. DOI:10.1016/0092-8674(90)90476-U. PMID 2160854.
- Squinto SP, Stitt TN, Aldrich TH, Davis S, Bianco SM, Radziejewski C, Glass DJ, Masiakowski P, Furth ME, Valenzuela DM (May 1991). „trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor”. Cell 65 (5): 885–93. DOI:10.1016/0092-8674(91)90395-F. PMID 1710174.
- Rose CR, Blum R, Pichler B, Lepier A, Kafitz KW, Konnerth A (November 2003). „Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells”. Nature 426 (6962): 74–8. DOI:10.1038/nature01983. PMID 14603320.
- Ohira K, Kumanogoh H, Sahara Y, Homma KJ, Hirai H, Nakamura S, Hayashi M (February 2005). „A truncated tropomyosin-related kinase B receptor, T1, regulates glial cell morphology via Rho GDP dissociation inhibitor 1”. J. Neurosci. 25 (6): 1343–53. DOI:10.1523/JNEUROSCI.4436-04.2005. PMID 15703388.
- Yamada K, Nabeshima T (2004). „Brain-derived neurotrophic factor/TrkB signaling in memory processes.”. J. Pharmacol. Sci. 91 (4): 267–70. DOI:10.1254/jphs.91.267. PMID 12719654.
- Soppet D, Escandon E, Maragos J, et al. (1991). „The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor.”. Cell 65 (5): 895–903. DOI:10.1016/0092-8674(91)90396-G. PMID 1645620.
- Squinto SP, Stitt TN, Aldrich TH, et al. (1991). „trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor.”. Cell 65 (5): 885–93. DOI:10.1016/0092-8674(91)90395-F. PMID 1710174.
- Haniu M, Talvenheimo J, Le J, et al. (1995). „Extracellular domain of neurotrophin receptor trkB: disulfide structure, N-glycosylation sites, and ligand binding.”. Arch. Biochem. Biophys. 322 (1): 256–64. DOI:10.1006/abbi.1995.1460. PMID 7574684.
- Ip NY, Stitt TN, Tapley P, et al. (1993). „Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells.”. Neuron 10 (2): 137–49. DOI:10.1016/0896-6273(93)90306-C. PMID 7679912.
- Slaugenhaupt SA, Blumenfeld A, Liebert CB, et al. (1995). „The human gene for neurotrophic tyrosine kinase receptor type 2 (NTRK2) is located on chromosome 9 but is not the familial dysautonomia gene.”. Genomics 25 (3): 730–2. DOI:10.1016/0888-7543(95)80019-I. PMID 7759111.
- Shelton DL, Sutherland J, Gripp J, et al. (1995). „Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins.”. J. Neurosci. 15 (1 Pt 2): 477–91. PMID 7823156.
- Allen SJ, Dawbarn D, Eckford SD, et al. (1994). „Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain.”. Neuroscience 60 (3): 825–34. DOI:10.1016/0306-4522(94)90507-X. PMID 7936202.
- Rydén M, Ibáñez CF (1996). „Binding of neurotrophin-3 to p75LNGFR, TrkA, and TrkB mediated by a single functional epitope distinct from that recognized by trkC.”. J. Biol. Chem. 271 (10): 5623–7. DOI:10.1074/jbc.271.10.5623. PMID 8621424.
- Yamamoto M, Sobue G, Yamamoto K, et al. (1997). „Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues.”. Neurochem. Res. 21 (8): 929–38. DOI:10.1007/BF02532343. PMID 8895847.
- Valent A, Danglot G, Bernheim A (1997). „Mapping of the tyrosine kinase receptors trkA (NTRK1), trkB (NTRK2) and trkC(NTRK3) to human chromosomes 1q22, 9q22 and 15q25 by fluorescence in situ hybridization.”. Eur. J. Hum. Genet. 5 (2): 102–4. PMID 9195161.
- Haniu M, Montestruque S, Bures EJ, et al. (1997). „Interactions between brain-derived neurotrophic factor and the TRKB receptor. Identification of two ligand binding domains in soluble TRKB by affinity separation and chemical cross-linking.”. J. Biol. Chem. 272 (40): 25296–303. DOI:10.1074/jbc.272.40.25296. PMID 9312147.
- Nakamura T, Muraoka S, Sanokawa R, Mori N (1998). „N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling.”. J. Biol. Chem. 273 (12): 6960–7. DOI:10.1074/jbc.273.12.6960. PMID 9507002.
- Hackett SF, Friedman Z, Freund J, et al. (1998). „A splice variant of trkB and brain-derived neurotrophic factor are co-expressed in retinal pigmented epithelial cells and promote differentiated characteristics.”. Brain Res. 789 (2): 201–12. DOI:10.1016/S0006-8993(97)01440-6. PMID 9573364.
- Iwasaki Y, Gay B, Wada K, Koizumi S (1998). „Association of the Src family tyrosine kinase Fyn with TrkB.”. J. Neurochem. 71 (1): 106–11. DOI:10.1046/j.1471-4159.1998.71010106.x. PMID 9648856.
- Qian X, Riccio A, Zhang Y, Ginty DD (1999). „Identification and characterization of novel substrates of Trk receptors in developing neurons.”. Neuron 21 (5): 1017–29. DOI:10.1016/S0896-6273(00)80620-0. PMID 9856458.
- Bibel M, Hoppe E, Barde YA (1999). „Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR.”. EMBO J. 18 (3): 616–22. DOI:10.1093/emboj/18.3.616. PMC 1171154. PMID 9927421.
- Yamada M, Ohnishi H, Sano S, et al. (1999). „Brain-derived neurotrophic factor stimulates interactions of Shp2 with phosphatidylinositol 3-kinase and Grb2 in cultured cerebral cortical neurons.”. J. Neurochem. 73 (1): 41–9. DOI:10.1046/j.1471-4159.1999.0730041.x. PMID 10386953.
- Ultsch MH, Wiesmann C, Simmons LC, et al. (1999). „Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.”. J. Mol. Biol. 290 (1): 149–59. DOI:10.1006/jmbi.1999.2816. PMID 10388563.
- Memories are made of this molecule - New Scientist, 15 January 2007.
