A work whose premise includes at least one Fantasy or Science Fiction element, often an Amusing Alien. These were especially popular in television Sitcoms of The '60s, as writers and networks cast about for novel alternatives to the more conventional Dom Coms of the preceding years.
See also: Comic Fantasy, Magic Realism, Mundane Fantastic, Urban Fantasy, Life Embellished, and Monster Roommate. Not to be confused with a comedy that just happens to be very good. Compare Supernatural Soap Opera for a more serious action- and drama-filled version which focuses more on the supernatural world instead of trivial everyday things.
Fantastic Comedies:
open/close all folders
Anime & Manga
Fantasy
Science Fiction
- Ah! My Goddess: Average college student accidentally becomes the boyfriend of a goddess.
- Akazukin Chacha: An inept Red Riding Hood Replica and her two male friends go on wacky adventures together.
- Delicious in Dungeon: A band of fantasy heroes learn about cooking and surviving in a dungeon from a veteran adventurer.
- Hime-chan's Ribbon: A middle school-aged Tomboy with a Girly Streak gets a magic ribbon from her magical kingdom counterpart.
- Itoshi No Ko Charlotte: An amateur necromancer manages to resurrect his dead love interest. Weird and wacky hijinks ensue.
- The Legend of Zelda: The Wind Waker - Link's Log Book: A 4-Koma take on The Legend of Zelda: The Wind Waker written by ÖYSTER and published by Futabasha.
- Magical Girl Incident: An office worker is suddenly turned into a magical girl.
- Magical★Taruruto-kun: An unlucky 5th-grader goes through life and bizarre adventures with a kindergarten-aged magician, both of whom become surrogate brothers.
- Miss Kobayashi's Dragon Maid: An office lady discovers that a dragon whose life she saved is now her new live-in servant.
- Yo Kai Watch: Strange creatures meddle with the life of a middle-schooler.
Science Fiction
- The Daichis - Earth's Defense Family: This work marks mecha designer as well as Macross and Aquarion creator, Shōji Kawamori's very first comedy anime series that he was involved with who normally only does serious works. Its about a dysfunctional family who are contractually obligated for 6 months to defend the earth from taking over the earth while also staying under budget. Situations primarily consits of Teeth-Clenched Teamwork whenever they don't cooperate and the characters being unhinged in general. The situations are usually presented in a comedic fashion, but this results in dark comedy due to the context. It also has numerous amounts of Toilet Humor depicted in the series.
- Doraemon: Robot cat travels 100 years in the past to give guidance to a hapless 10 year old boy.
- Genji Tsuushin Agedama: A Kid Hero from another galaxy, his living word processor, and his new love interest are all stuck in an ongoing feud with the city's local Rich Bitch and not-so-secret supervillainess.
- My Hero Academia: A Wacky Homeroom of 20 is taught about how to become superheroes in a world where Everyone Is a Super. Chaos and rivalry ensues.
- Tsuritama: An anime series which focuses on the friendship between Yuki, an Ordinary High-School Student with social difficulties, and Haru, an odd and hyperactive alien. They save the world, by fishing.
Asian Animation
Science Fiction
- Happy Friends: Robot Kid superheroes defend their home planet from various monsters of the week, with plenty of comedic tropes (including several jokes that use Breaking the Fourth Wall and Lampshade Hanging) thrown in for good measure.
- Pleasant Goat and Big Big Wolf: The later seasons retain the comedy aspect of the older seasons while having stories with largely science-fiction elements (compared to earlier seasons which were slapstick), from exploring the insect world while as small as an insect to ocean exploration to time travel.
- Rocket Boy & Toro: It's about a robot delivery boy who serves all of outer space. The primary bad guy is a supercomputer and his robotic assistant, and alternate universes and time travel are among the subjects found in certain episodes. There's plenty of comedy, whether it's puns, silly situations like someone deciding to wear a pizza on his head, or other things entirely.
Fan Works
Fantasy
- The Calvinverse: World of Weirdness antics abound in these very Medium Aware Script Fics.
Films — Animation
Fantasy
Science Fiction
- Inside Out: Coming of Age film centered on the anthropomorphic emotions in the mind of a young girl.
- Shrek: The definitive Fractured Fairy Tale franchise set in a world of ogres and swashbuckling cats.
- Smurfs: The Lost Village
- Smurfs
- Turning Red: Coming of age comedy about a girl who can turn into a giant red panda.
- Twice Upon a Time
Science Fiction
- Hoppers: Comedy film about a young woman piloting a robotic beaver to save a local patch of forest.
- Lifted: Short film about an alien taking the equivalent of a driving test for abducting humans.
- Lilo & Stitch (2002): Comedy film about a young girl who unknowingly adopts an alien fugitive.
- The Mitchells vs. the Machines: A robot uprising breaks out during a dysfunctional family’s road trip.
- Teenage Mutant Ninja Turtles: Mutant Mayhem: Coming of age comedy involving mutants and monsters.
- WALL•E: A romantic comedy about two robots on a post-apocalyptic Earth.
Films — Live-Action
Fantasy
Science Fiction
- Barbie (2023): Product placement film about a living doll who questions her own mortality.
- Bewitched: The actress playing Samantha in a new reboot of the '60s sitcom is secretly a real-life witch.
- Bruce Almighty: God grants most of his omnipotent powers to Bruce Nolan, a down-on-his-luck TV news reporter. Bruce proceeds to comically abuse his new Reality Warper abilities.
- Evan Almighty: Sequel where God appoints newsman-turned-politician Evan Baxter to become a modern-day prophet in the vein of Noah, warning Washington DC of another Great Flood.
- Dear Santa: A young boy tries to write a letter to Santa but accidentally summons Satan due to his poor spelling.
- Dungeons & Dragons: Honor Among Thieves: A motley group of thieves improvises and snarks their way through a heist in a fantasy setting
- Ghost Dad
- Ghosts of Girlfriends Past
- Ghost Town (2008): A dentist has the ability to see and converse with ghosts.
- Heavens to Betsy: A woman accuses God of not answering her prayers. God responds by placing her in an alternate reality where she received every single thing she ever prayed for in her life.
- Hot to Trot: A man inherits a talking horse from his mother.
- Jabberwocky
- Farador: A group of friends play the same D&D campaign for 18 years.
- Kaamelott: First Installment
- Liar Liar: A boy's birthday wish that his father be prevented from telling a single lie for 24 hours is granted.
- The Librarian
- A Minecraft Movie
- Monty Python and the Holy Grail
- Oh! Heavenly Dog
- Red One
- Ted: Fantasy film about a teddy bear who came to life because of a child’s wish and grew up into a foul-mouthed slacker.
- Ted 2: The living teddy bear must now fight to prove his personhood in court.
- This Is the End: Horror Comedy about several self-centered, obnoxious celebrities trying to survive a global apocalypse, which turns out to be the same apocalypse prophesied in the Bible, in which demons invade the world.
- Les Visiteurs Film Series: A medieval French knight and his squire travel in time. Wizards and witches exist in their version of The Middle Ages.
- Les Visiteurs
- Les Visiteurs II: The Corridors of Time
- Les Visiteurs: Bastille Day
- Just Visiting: Remake of the first film.
- Violent Night: Die Hard 1 starring Santa Claus.
- Willy Wonka & the Chocolate Factory
Science Fiction
- Deadpool (2016)
- Everything Everywhere All at Once is a Science Fiction Wuxia film about a Dysfunctional Family getting involved in a war to save The Multiverse, with a lot of Surreal Humor from the dimension hopping the characters partake in.
- Lilo & Stitch (2025)
- The Man with Two Brains
- Mars Attacks!: An Alien Invasion movie that is Played for Laughs.
- Me, Myself & The Void
- Men in Black: Action-comedy movies about The Men in Black policing alien visitors on Earth. Much of the humor comes from just how weird the aliens can be, among other things.
- The Nutty Professor (1963)
- The Nutty Professor (1996)
- The Rocky Horror Picture Show
- Santa Claus Conquers the Martians: Santa Claus is kidnapped so he can bring Christmas to Mars.
- Sonic The Hedgehog Film Series
- They Cloned Tyrone: A sci-fi Conspiracy Thriller in which a man discovers he has been cloned as part of a vast conspiracy.
- Le Visiteur du Futur (The Movie of the series)
Literature
Fantasy
- Each Little Universe: Two slacker inventors meet a girl from the stars; hijinks ensue.
Live-Action TV
Fantasy
Science Fiction
Science Fantasy
- 31 Minutos
- The Addams Family (1964): The daily life of eccentric millionaire Gomez Addams and his macabre but loving family, who live in a haunted house.
- Bewitched: Ad exec Darrin Stevens tries to live with his witch wife Samantha and her crazy family of magicians, witches, and warlocks.
- Big Wolf on Campus: A teenage werewolf, his best-friend and an Action Girl deal with the Monster of the Week, making movie references all the way.
- Boy Meets World (Featured Crossovers with Sabrina the Teenage Witch (1996), Time Travel, Eric temporarily developing Psychic Powers, and Chet Hunter's ghost.)
- Captain Nice: A mild-mannered mama's boy who discovers a secret formula that, when taken, transformed him in an explosive burst of smoke into superhero Captain Nice.
- Cavemen: Based on the "Cavemen" Geico campaign, Present day with Cavemen still existing and being integrated into Homo sapiens as a seperate sub-group.
- The Charmings: Snow White, Prince Charming, kids and wicked witch mother-in-law all in modern suburbia.
- Dead Gorgeous: The main protagonists are 150 year old ghosts suddenly dropped into a modern school.
- Dead Like Me: Mundane Fantastic Black Dramedy about Grim Reapers who escort the newly-deceased to their last stop and otherwise try to lead relatively normal "lives" in the world of the living.
- Dog with a Blog: A dog with a blog who can talk.
- Dwight in Shining Armor
- Eerie, Indiana: Think The X-Files turned into a comedy for kids.
- The Flying Nun: About a nun who, well, flies.
- Free Spirit (1989): Blithe Spirit with magical powers becomes a Magical Nanny to a divorced lawyer's kid.
- The Genie from Down Under: A snobbish British girl discovers an opal housing a father/son pair of very Aussie genies. The genies attempt to earn their freedom while a Penelope attempts to make wishes the Literal Genies cannot cause to backfire.
- Genie in the House: British sitcom about an apprentice genie living with a father and his two teenage daughters.
- The Ghost and Mrs. Muir: Family lives in a cottage haunted by an old sea captain's ghost.
- Ghosts (UK): A couple inherit a Haunted House and must deal with ghosts.
- Ghosts (US): Same as Ghosts (UK), but adapted for an American audience.
- Ghosts Australia: The Australian adaptation.
- Gilligan's Island
- The Good Place: A troubled woman navigates a mundane afterlife and tries to figure out how she wound up there, while trying to behave herself and debating philosophy with her neighbors.
- Happy!: Based on a comic by Grant Morrison, an alcoholic ex-cop turned hitman teams up with a girl's Imaginary Friend to save her.
- The Haunted Hathaways
- Hero Corp
- I Dream of Jeannie: An astronaut discovers a Persian genie in a bottle while stranded on a deserted island, who ends up following him home.
- It's Garry Shandling's Show: A Sitcom about having your own Sitcom. Reality is frequently out to lunch, with mile-tall treehouses and time machines.
- Joséphine, ange gardien: A Guardian Angel with some magical powers descends from the sky to help people.
- Kaamelott deals with the Arthurian legends (including wizard, magic sword and all) from a comedic point of view.
- Laid is a comedy about a woman discovering all of her previous sexual partners are rapidly dying in order, and eventually rules out every possibility except a supernatural explanation.
- The Lost Saucer: Gomer Pyle and Ruth Buzzi as androids.
- Marley's Ghosts: Woman finds that she can see ghosts, and lives with the ghosts of her recently dead husband, affair, and the local Vicar.
- The Mighty Boosh
- Mister Ed: An architect moves to the country, and befriends a talking horse.
- The Munsters: Adventures of a working class suburban family who happen to be a Frankenstein's monster, his vampire wife and father-in-law, werewolf son, and normal-looking teenage niece.
- The Muppet Show: Human guest stars appear on a vaudevillian variety show entirely composed of talking animals and stranger beings. Magical and/or science fiction sub-plots are common.
- My Living Doll: Psychiatrist is entrusted with the care of a lifelike female android.
- My Mother the Car: David Crabtree drives an antique car that is the reincarnation of his mother.
- My Phone Genie: Genie in a phone.
- Nanny and the Professor: A college professor discovers the new nanny to his three children has psychic powers.
- 100 Deeds for Eddie McDowd: The neighborhood bully is transformed into a talking dog, and has to complete 100 good deeds before he can be turned back into a human being.
- Pushing Daisies: A baker with the ability to bring back the dead investigates crimes.
- Rentaghost: A company of ghosts for hire.
- Round the Twist: Three siblings move into a lighthouse with their dad, in an isolated community where they become Weirdness Magnets for the supernatural.
- Sabrina the Teenage Witch (1996): A high school girl from a Witch family navigates everyday life.
- Seriously Weird: Harris Pembleton, a new arrival from England, becomes a magnet for all that is weird after he disrespects Steve, the Ruler of The Weird Dimension.
- Scorch: A 1,300-year-old teen dragon crash lands into the apartment of a single father and his daughter, where he pretends to be a ventriloquist puppet for the father's weatherman job.
- Seven & Me: A Kid Com about the descendant of a Fairy Tale character. One of the protagonists is a wizard.
- Sigmund and the Sea Monsters: Two boys help a sea monster avoid his ruthless, abusive family.
- Son of Zorn: Zorn, a cartoon barbarian similar to He-Man who comes from the magical South Pacific island of Zephyria, reconnecting with his live-action family in Orange County, California.
- Ted: Prequel series about a foul-mouthed living teddy bear and his human friend surviving high-school.
- Teen Angel: One of the main characters is a Guardian Angel.
- That's So Raven: A teenage girl finds her life complicated by psychic visions of the future.
- Raven's Home, a spin-off with Raven's son who is also a psychic.
- Topper: One of the earliest examples of the trope - The ghosts of a young couple killed in an avalanche [as well as the ghost of the St Bernard that tried to rescue them] try to help an uptight Banker loosen up and enjoy life.
- Wizards of Waverly Place: A trio of young Wizards in New York City.
- Woof!: A kid finds himself constantly turning in a dog for unexplained reasons.
- Yonderland: A stay-at-home mum is chosen to be the saviour of a magical world.
- Young Dracula: Some of the main characters are vampires.
- Your Pretty Face Is Going to Hell (Black Comedy about workers in hell)
Science Fiction
- ALF: An alien crash lands in suburbia and moves in with a human family.
- Aliens in the Family: Alien falls in love with her abduction victim and they raise their five kids on Earth.
- Boldly Going Nowhere: Parody of Space Operas about the incompetent and borderline crazy crew of a rock-collecting spaceship.
- Come Back Mrs. Noah: A suburban housewife and a small crew are trapped on a space station that is accidentally launched.
- Cybervillage: A farmer family on Mars is fighting a Railroad Plot by a Corrupt Corporate Executive
- Dani's House: Dani is a teenage actress and singer who is regularly left in charge of her younger brother Max, his friend Ben, and their youngest sibling, "the baby from hell". She and her friends Toby and Sam spend most of their time at her house in a den hangout. As they go about their lives, they encounter some bizarre situations. Meanwhile, two aliens known as Coordinators (Coordinator Zang and Coordinator Zark) observe their actions.
- Family Matters: Later in the series, Teen Genius Steve Urkel's inventions reached Applied Phlebotinum levels.
- Far Out Space Nuts: NASA janitors try to return to Earth after an accidental launch.
- Flander's Company: Office life in a supervillain company. Mixes superpowers and super-technology.
- Future Man
- Goodnight Sweetheart: Modern hero discovers time portal to 1940's London, the exact nature of which was never made entirely clear to either him or the audience.
- Heat Vision and Jack takes its absurd premise of a NASA astronaut on the run with his best friend-turned-motorcycle mostly seriously.
- Herman's Head: Four characters representing the thought processes of an office worker help him navigate life.
- The Hitchhiker's Guide to the Galaxy (1981): An ordinary British fellow is rescued from the destruction of Earth, and travels the cosmos with his long-time friend who turns out to be an alien.
- Homeboys in Outer Space: Two men and a lovestruck computer explore the universe.
- Honey, I Shrunk the Kids: Adaptation of the film series, focusing on the further adventures of Wayne Szalinski and his family.
- I Am Frankie
- It's About Time was based on the Fish out of Temporal Water trope. It started with two astronauts accidentally Time Traveling back to the prehistoric era and making friends with a family of cave dwellers. When the show got disappointing ratings, a mid-season Retool resulted in the astronauts returning to their own time — with the cave family in tow.
- Knuckles
- Lab Rats: A trio of bionic superhuman teens.
- Marvin Marvin: An Alien Among Us Kid Com.
- Mork & Mindy: Alien moves in with suburbanite woman, learns about humans.
- My Favorite Martian: Ray Walston plays an alien visitor passed off as Bill Bixby's uncle.
- My Hero (2000): Superman-like hero married to normal woman.
- My Living Doll: Air Force psychologist lives with beautiful woman-shaped robot.
- My Parents Are Aliens (well, foster parents, at any rate)
- Mystery Science Theater 3000 A human and his Robot Buddies are imprisoned on a Space Station by a Mad Scientist and his/her henchmen, who force them to watch bad movies.
- The Neighbors: Amusing Aliens in suburbia who take on the appearance of a multiethnic family (white husband, black wife, Asian son, white daughter) with the names of famous American athletes.
- The Orville: A parody of Star Trek about a space captain and his ex-wife having to learn to get along while exploring deep space.
- Other Space: Rookie space explorers sent on mission, stumble into alternate universe by accident.
- Out of This World (1987): Girl given time-stopping ability by her father, an alien.
- People of Earth: A small-time journalist seeks info for his next article by going undercover in an alien abductee support group. He slowly learns that this group isn't as crazy as they seem while audiences get to watch a group of aliens freak out that their abduction victims are slowly uncovering what they did.
- Phil of the Future: A family from the future gets trapped in modern times.
- Quark: A short-lived sci-fi parody about the captain of an intergalactic garbage scow and his ragtag crew.
- Red Dwarf: An average bloke is put in stasis for 18 months, accidentally stays in for millions of years, wakes up on a mining ship with no one for company but a hologram of his old bunkmate, a mutant descended from the offspring of his pregnant cat, a bumbling robot, and a sarcastic AI.
- Santa Clarita Diet: A real estate agent from suburban California turns into an undead cannibal, while her husband and daughter try to cope with it.
- Small Wonder: A suburban family lives with their android daughter.
- The Strangerers: Two aliens in disguise as humans awkwardly try to blend into human society whilst on a fact-finding mission complicated by the death of their supervisor.
- 3rd Rock from the Sun: Alien explorers masquerade as a human family.
- The Thundermans: A family of superheroes trying to settle down so three kids can have a normal childhood.
- The Thundermans Undercover: Siblings of a superhero family go undercover as civilians to stop a threat to their visiting neighborhood.
- Trip for Biscuits: PI agency investigate alien phenomena, with hilarious results.
- Upload: Series set 20 Minutes into the Future, which focuses on a 27 year old who is uploaded to a corporately-owned Artificial Afterlife after dying in a self-driving car accident.
- Vampire Idol: A vampire alien crown prince and his three loyal bodyguards have to learn to navigate Earth customs while finding love and training to be K-pop idol stars.
- The Villains of Valley View: A family of supervillains trying to live normal lives in hiding after offending the leader of all villains.
- Weird Science (1994): Two boys and their computer-generated magic genie.
Science Fantasy
- Don't Hug Me I'm Scared
- No Heroics, superheroes in their everyday lives.
- Pixelface: Set inside a games console and starring video game characters in their downtime. Also features scenes set in the characters' games.
- The Tick (2001) is about the daily lives of superheroes (rather than their exciting adventures).
- WarpZone Project (multiple superhero series)
Podcasts
Fantasy
- Le Donjon de Naheulbeuk: Affectionate Parody of fantasy RPGs with a stereotypical roster of adventurers.
- Less is Morgue: An Odd Couple comedy about a peppy ghost girl and a paranoid ghoul hanging out and running an amateur talk show in a paranormal version of Tallahassee, Florida.
Radio
Fantasy
Science Fiction
- Old Harry's Game: The series takes place in Hell and focuses on Satan who gets into humorous debates with the more idealistic Professor.
Science Fiction
- Welcome to Our Village, Please Invade Carefully: Amusing but potentially very nasty aliens take over an English village.
Theatre
Fantasy
- The Thousand Year Rose: Three sassy witches hunt for the legendary treasure in Ireland sealed by a rose that will only bloom for somebody with a pure heart.
Web Animation
Fantasy
Science Fiction
Science Fantasy
- The God And Devil Show: God and a female Devil host a talk show.
- Mighty Magiswords: Brother–Sister Team have misadventures wielding different types of silly swords.
Science Fiction
- Lobo (Webseries): An alien bounty hunter has hilarious, gory and profane adventures.
- Slim Chance Intergalactic Zoologist: A clone of a clone hosts a zoology show.
- Starship Regulars: A Work Com styled after Star Trek.
- The Stump: An alien nerd moves to another middle school.
Science Fantasy
- Matt 'n' Dusty: Includes robots, dragons, sentient game consoles, and dolphins wishing to take over the planet.
- Narez: The series includes robots, flying animal & genies.
- Supermarioglitchy4's Super Mario 64 Bloopers
Web Comics
Fantasy
Science Fiction
- All Saints Street: The daily lives of monsters that share an apartment together.
- Life In Stripes: Humans cursed into animals and what this means for their lives, usually for comedy.
- Rooftops And Roomates: The misadventures of a gargoyle college student trying to hide his true nature.
Science Fiction
Web Video
Fantasy
Science Fiction
- Adventure Is Nigh!
- Dungeon Flippers A real estate agency sells dungeons in a Standard Fantasy Setting.
- Steve D'Monster
- Transylvania Television: Vampire, Yeti, Bat, Skull, Frankenstein Monster and a large workforce of zombies run a television station.
Science Fiction
- Dad
- Space Janitors: Janitors in space.
- The Time... Guys: Time-travelling scientist, his plucky young ward, and his Neanderthal intern.
- Transolar Galactica: Star Trek/Battlestar Galactica/military sci-fi parody.
- Le Visiteur du Futur: Centered on Time Travel. Science Fantasy
- Don't Hug Me I'm Scared
- SuperMarioLogan
Western Animation
Fantasy
Science Fiction
Science Fantasy
- The Amazing World of Gumball: Covers the lives of the Wattersons and their friends and neighbors, in an extremely surreal world where Everything Talks.
- Amphibia: Asian-American girl ends up trapped in a world of talking amphibians.
- Billy Dilley's Super Duper Subterranean Summer: Three kids who are science lab partners get trapped in a world underground.
- Dave the Barbarian: An Affectionate Parody of Heroic Fantasy in general and Conan the Barbarian in particular; teens Dave and Candy and their kid sister Fang rule over a fantasy land with their eccentric wizard Uncle Oswidge.
- Disenchantment: Cartoon parodying Medieval European Fantasy tropes, from the same creator of Futurama.
- The Epic Tales of Captain Underpants: Based on the book series by Dav Pilkey, two mischief-loving elementary schoolers hypnotize their grumpy principal into becoming a super-hero to deal with various strange and fantastic threats.
- The Fairly OddParents!: An average kid has Fairy Godparents and can wish for anything at any time. Naturally, chaos ensues.
- God, the Devil and Bob: God and Satan decide to involve themselves in the life of a random guy named Bob, a blue-collar family man from Detroit.
- The Grim Adventures of Billy & Mandy: The Grim Reaper is tricked into becoming a slave at the whims two children who torment and embarrass him, all while dealing with a Rogues Gallery from the underworld.
- Haunted Hotel (2025): An adult animated comedy about a family trying to run a hotel filled to the brim with ghosts and demons.
- Hilda: A young girl and her friends getting into fantastical misadventures in their hometown.
- Jackie Chan Adventures: Action-adventure-comedy about Jackie Chan, his hyperactive niece, and their eccentric uncle traveling around the world to fight criminals, demons, and evil sorcerers. Lots of slapstick humor and magical antics ensue.
- Jimmy Two-Shoes: An average kid ends up in a Hell-like setting while dealing with various monsters, including Satan and his bumbling, goody two-shoes son.
- Krapopolis: A dysfunctional family of gods and fantasy creatures attempt to run an early city in Ancient Greece.
- The Owl House (The Demon Realm as the main setting and the main characters are witches & monsters)
- Pelswick (Protagonist has a guardian angel)
- Sabrina: The Animated Series, though slightly more adventure-themed.
- SpongeBob SquarePants : Funny Animal sea creatures live in an underwater town.
- Star vs. the Forces of Evil: A magical princess from another dimension has access to powerful magic, but has trouble controlling it. She moves in with an ordinary boy, and causes all sorts of trouble.
- Ugly Americans: Every supernatural or mythological being is real, and have the same problems as any other minority groups.
- Wishfart: Every character in the show is a different type of magical creature, from leprechauns to ghosts to talking animals to mermaids.
- YooHoo & Friends: Five greedy, corporate executives are turned into cute, cuddly animals by Father Time. In order to become humans again, they have to atone for their actions by fixing the mess they've made and helping out the environment.
Science Fiction
- American Dad!, which is a bit more sci-fi than its predecessor.
- Duckman is supposedly about the home and work life of an irascible detective, but features mad scientists, berserk computers, alien abductions, reincarnation, and the near-destruction of the universe by White Out.
- Evil Con Carne: A brain attached to a purple bear wants to take over the world.
- Final Space
- Fired on Mars
- Futurama: Unlucky Everydude from 1999 AD trapped in stasis for 1000 years, winds up living in the 31st century.
- I Am Not an Animal: Collage animation satire about self-obsessed talking animals created in a lab.
- Inside Job (2021): A satirical Work Com about a private company which helps manipulate global affairs for an evil secret society that rules the world, and are involved with every single political conspiracy or paranormal legend one can think of (including aliens and lizard people).
- Invader Zim: An evil alien spy infiltrates the planet Earth, trying (and failing) to conquer it for his people.
- The Jetsons: An ordinary family who happen to live in the future.
- Men in Black: The Series: Animated Adaptation of Men In Black.
- Outer Space Astronauts
- Rick and Morty: A mad scientist takes his loser grandson on intergalactic, and interdimensional adventures.
- Sonic Boom: A team of your favorite superpowered animals face mundane situations in their mundane village while facing off with a mad scientist and his Mecha-Mook (as well as other fantastic things).
- Strange Planet (2023)
- Tripping the Rift: A Ragtag Bunch of Misfits have crazy misadventures in the non-controlled areas of space.
Science Fantasy
- Attack of the Killer Tomatoes (1990)
- The Baskervilles: An animated show about a British family living in the most twisted theme park in the world.
- Coconut Fred's Fruit Salad Island: The main character has the ability to make things real by imagining them. Much of the humor is in a typical Zany Cartoon fashion.
- Courage the Cowardly Dog: A Horror Comedy cartoon about a talking dog who confronts various supernatural monsters that threaten his elderly owners and their home.
- Gravity Falls: Twin siblings spend the summer in the eponymous town, where they encounter a wide variety of creatures including gnomes, living wax statues, and macho minotaurs.
- The Hollow
- Regular Show: A cartoon about the surrealistic misadventures of two slacker friends — an anthropomorphic bird and a raccoon — along with their coworkers in an urban park.
- Treehouse of Horror: An annual series of The Simpsons Halloween episodes that parody horror, fantasy, and science fiction stories.
- Uncle Grandpa: The main character is a Reality Warper who travels the world helping out youngsters in his own strange way; other main characters include a Godzilla-like lizard man, a talking fanny pack, a sentient pizza slice, a photorealistic tiger, and a robot.
- Villainous: A cartoon about a supervillain organization; its main characters include an ancient demon and a mad scientist.
- When I Was Your Age (2024)