Can Gemma 3 27B run on AMD Instinct MI300A 128GB?

YES — Runs Great

A81Great

○Estimated from fit model

Gemma 3 27B needs ~41.4 GB VRAM. AMD Instinct MI300A 128GB has 128.0 GB. With Q4_K_M quantization, expect ~140 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 41.4 GB, 147.0 tok/s, Runs well

41.4 GB required128.0 GB available

32% VRAM used

Fit status

Runs well

Decode

147.0 tok/s

TTFT

1317 ms

Safe context

131K

Memory

41.4 GB / 128.0 GB

Memory breakdown

Weights16.5 GB

KV Cache11.2 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsGemma 3 27B on AMD Instinct MI300A 128GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
 if len(arr) <= 1:
 return arr
 pivot = arr[len(arr) // 2]
 left = [x for x in arr if x < pivot]
 middle = [x for x in arr if x == pivot]
 right = [x for x in arr if x > pivot]
 return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers)) # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
 """Sort a list using the quicksort algorithm.

 Args:
 arr: List of integers to sort.

 Returns:
 A new sorted list.
 """
 if len(arr) <= 1:
 return arr
 pivot = arr[len(arr) // 2]
 left = [x for x in arr if x < pivot]
 middle = [x for x in arr if x == pivot]
 right = [x for x in arr if x > pivot]
 return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 147.0 tok/s decode · 1.3s TTFT (warm) · 368 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	140.0 tok/s	754 ms	131K
Coding	A	Runs well	140.0 tok/s	1383 ms	131K
Agentic Coding	A	Runs well	140.0 tok/s	2012 ms	131K
Reasoning	A	Runs well	140.0 tok/s	1634 ms	131K
RAG	A	Runs well	140.0 tok/s	2515 ms	131K

Quantization options

How Gemma 3 27B (27B params) fits at each quantization level on AMD Instinct MI300A 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	10.5 GB	Low	A71
Q3_K_S	3	13.2 GB	Low	A71
NVFP4	4

Get started

Copy-paste commands to run Gemma 3 27B on your machine.

Run

ollama run gemma3

Your hardware

More models your AMD Instinct MI300A 128GB can run

Model	Params	Grade	Decode	Capabilities
👁 Mistral Devstral 2 123B Instruct	123B	S	53.8 tok/s
👁 Alibaba Qwen3-Coder 30B A3B Instruct	30.5B	S

Frequently asked questions

See all results for AMD Instinct MI300A 128GB See all hardware for Gemma 3 27B

URL: https://willitrunai.com/can-run/gemma-3-27b-on-instinct-mi300a-128gb

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