Can Gemma 4 31B run on AMD Instinct MI250 128GB?

YES — Runs Great

S86Excellent

○Estimated from fit model

Gemma 4 31B needs ~47.1 GB VRAM. AMD Instinct MI250 128GB has 128.0 GB. With Q4_K_M quantization, expect ~76 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 47.1 GB, 75.8 tok/s, Runs well

47.1 GB required128.0 GB available

37% VRAM used

Fit status

Runs well

Decode

75.8 tok/s

TTFT

2553 ms

Safe context

104K

Memory

47.1 GB / 128.0 GB

Memory breakdown

Weights18.7 GB

KV Cache14.6 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsGemma 4 31B on AMD Instinct MI250 128GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
 if len(arr) <= 1:
 return arr
 pivot = arr[len(arr) // 2]
 left = [x for x in arr if x < pivot]
 middle = [x for x in arr if x == pivot]
 right = [x for x in arr if x > pivot]
 return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers)) # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
 """Sort a list using the quicksort algorithm.

 Args:
 arr: List of integers to sort.

 Returns:
 A new sorted list.
 """
 if len(arr) <= 1:
 return arr
 pivot = arr[len(arr) // 2]
 left = [x for x in arr if x < pivot]
 middle = [x for x in arr if x == pivot]
 right = [x for x in arr if x > pivot]
 return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 75.8 tok/s decode · 2.6s TTFT (warm) · 190 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	75.8 tok/s	1393 ms	104K
Coding	S	Runs well	75.8 tok/s	2553 ms	104K
Agentic Coding	S	Runs well	75.8 tok/s	3714 ms	104K
Reasoning	S	Runs well	75.8 tok/s	3018 ms	104K
RAG	S	Runs well	75.8 tok/s	4643 ms	104K

Quantization options

How Gemma 4 31B (30.700000762939453B params) fits at each quantization level on AMD Instinct MI250 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	12.0 GB	Low	A75
Q3_K_S	3	15.0 GB	Low	A76
NVFP4	4	17.2 GB	Medium	A76
Q4_K_M	4	18.7 GB	Medium	A76
Q5_K_M	5	22.1 GB	High	A76
Q6_K	6	25.2 GB	High	A76
Q8_0	8	32.8 GB	Very High	A78
F16Best for your GPU	16	62.9 GB	Maximum	A83

Get started

Copy-paste commands to run Gemma 4 31B on your machine.

Run

ollama run gemma4:31b

Your hardware

More models your AMD Instinct MI250 128GB can run

Model	Params	Grade	Decode
👁 Mistral Devstral 2 123B Instruct	123B	S	31.5 tok/s
👁 Alibaba Qwen 3.5 122B A10B	122B	S	87.5 tok/s
👁 Alibaba Qwen 3.6 35B A3B	35B	S	276.5 tok/s
👁 Alibaba Qwen 3.5 35B A3B	35B	S	300.7 tok/s
👁 Alibaba Qwen 3 32B	32B	S	121.2 tok/s

Frequently asked questions

See all results for AMD Instinct MI250 128GB See all hardware for Gemma 4 31B

URL: https://willitrunai.com/can-run/gemma-4-31b-on-instinct-mi250-128gb

⇱ Gemma 4 31B on AMD Instinct MI250 128GB? YES