Can Gemma 4 E4B run on AMD Instinct MI60 32GB?

YES — Runs Great

A76Great

○Estimated from fit model

Gemma 4 E4B needs ~10.6 GB VRAM. AMD Instinct MI60 32GB has 32.0 GB. With Q4_K_M quantization, expect ~111 tok/s.

Runtime: OllamaCapacity: RoomyBandwidth: HighStack: BasicBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 10.6 GB, 110.5 tok/s, Runs well

10.6 GB required32.0 GB available

33% VRAM used

Fit status

Runs well

Decode

110.5 tok/s

TTFT

1752 ms

Safe context

128K

Memory

10.6 GB / 32.0 GB

Memory breakdown

Weights4.9 GB

KV Cache1.3 GB

Runtime1.2 GB

Headroom3.2 GB

See how fast it feels

See how fast it feelsGemma 4 E4B on AMD Instinct MI60 32GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
 if len(arr) <= 1:
 return arr
 pivot = arr[len(arr) // 2]
 left = [x for x in arr if x < pivot]
 middle = [x for x in arr if x == pivot]
 right = [x for x in arr if x > pivot]
 return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers)) # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
 """Sort a list using the quicksort algorithm.

 Args:
 arr: List of integers to sort.

 Returns:
 A new sorted list.
 """
 if len(arr) <= 1:
 return arr
 pivot = arr[len(arr) // 2]
 left = [x for x in arr if x < pivot]
 middle = [x for x in arr if x == pivot]
 right = [x for x in arr if x > pivot]
 return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 110.5 tok/s decode · 1.8s TTFT (warm) · 276 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	A	Runs well	110.5 tok/s	955 ms	128K
Coding	A	Runs well	110.5 tok/s	1752 ms	128K
Agentic Coding	A	Runs well	110.5 tok/s	2548 ms	128K
Reasoning	A	Runs well	110.5 tok/s	2070 ms	128K
RAG	A	Runs well	110.5 tok/s	3185 ms	128K

Quantization options

How Gemma 4 E4B (8B params) fits at each quantization level on AMD Instinct MI60 32GB (32.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	3.1 GB	Low	A70
Q3_K_S	3	3.9 GB	Low	A71
NVFP4	4	4.5 GB	Medium	A71
Q4_K_M	4	4.9 GB	Medium	A71
Q5_K_M	5	5.8 GB	High	A71
Q6_K	6	6.6 GB	High	A72
Q8_0	8	8.6 GB	Very High	A72
F16Best for your GPU	16	16.4 GB	Maximum	A76

Get started

Copy-paste commands to run Gemma 4 E4B on your machine.

Run

ollama run gemma4:e4b

Your hardware

More models your AMD Instinct MI60 32GB can run

Model	Params	Grade	Decode
👁 Alibaba Qwen3-Coder 30B A3B Instruct	30.5B	S	75.9 tok/s
👁 Alibaba Qwen 3.5 27B	27B	S	32.9 tok/s
👁 Alibaba Qwen 3.6 27B	27B	S	33 tok/s
👁 Alibaba Qwen 3.6 35B A3B	35B	S	63.8 tok/s
👁 Alibaba Qwen3-VL 30B A3B Instruct	30B	S	78.5 tok/s

Frequently asked questions

See all results for AMD Instinct MI60 32GB See all hardware for Gemma 4 E4B

URL: https://willitrunai.com/can-run/gemma-4-e4b-on-instinct-mi60-32gb

⇱ Gemma 4 E4B on AMD Instinct MI60 32GB? YES