Can Mistral Small 4 119B run on AMD Instinct MI250 128GB?

YES — Runs Great

S97Excellent

○Estimated from fit model

Mistral Small 4 119B needs ~91.7 GB VRAM. AMD Instinct MI250 128GB has 128.0 GB. With Q4_K_M quantization, expect ~87 tok/s.

Runtime: llama.cppCapacity: RoomyBandwidth: HighStack: StandardBottleneck: Balanced

Operating mode

Choose the run profile you care about

Interactive favors responsiveness, while light API and scale-out lean harder on serving readiness. The fit stays the same, but the recommendation lens changes.

Current mode

Balanced

Balanced for general local use. Keeps the ranking neutral across personal and serving workflows.

Capabilities:

Select quantization to explore

Q4_K_M (Medium quality) — 91.7 GB, 94.8 tok/s, Runs well

91.7 GB required128.0 GB available

72% VRAM used

Fit status

Runs well

Decode

94.8 tok/s

TTFT

2041 ms

Safe context

124K

Memory

91.7 GB / 128.0 GB

Memory breakdown

Weights72.6 GB

KV Cache5.4 GB

Runtime0.9 GB

Headroom12.8 GB

See how fast it feels

See how fast it feelsMistral Small 4 119B on AMD Instinct MI250 128GB
1st promptCold start — includes initialization
>Write a Python function to sort a list
Here's a Python function that sorts a list using quicksort:

def quicksort(arr):
 if len(arr) <= 1:
 return arr
 pivot = arr[len(arr) // 2]
 left = [x for x in arr if x < pivot]
 middle = [x for x in arr if x == pivot]
 right = [x for x in arr if x > pivot]
 return quicksort(left) + middle + quicksort(right)

# Example usage
numbers = [3, 6, 8, 10, 1, 2, 1]
print(quicksort(numbers)) # [1, 1, 2, 3, 6, 8, 10]

The algorithm picks a pivot, partitions the list into smaller, equal, and larger elements, then recursively sorts each partition and concatenates the results.
2nd promptWarm — model ready, no init overhead
>Now add type hints and a docstring
def quicksort(arr: list[int]) -> list[int]:
 """Sort a list using the quicksort algorithm.

 Args:
 arr: List of integers to sort.

 Returns:
 A new sorted list.
 """
 if len(arr) <= 1:
 return arr
 pivot = arr[len(arr) // 2]
 left = [x for x in arr if x < pivot]
 middle = [x for x in arr if x == pivot]
 right = [x for x in arr if x > pivot]
 return quicksort(left) + middle + quicksort(right)

Added type hints for the input and return type, plus a Google-style docstring.
Estimated: 94.8 tok/s decode · 2.0s TTFT (warm) · 237 tok/s prefill

What limits this setup

This setup is broadly balanced for this model.

No major red flags

This recommendation has enough memory headroom and acceptable estimated speed for the selected workload.

Best improvement path

Performance by workload

Workload	Grade	Fit	Decode	TTFT	Context
Chat	S	Runs well	87.2 tok/s	1211 ms	124K
Coding	S	Runs well	87.2 tok/s	2220 ms	124K
Agentic Coding	S	Runs well	87.2 tok/s	3229 ms	124K
Reasoning	S	Runs well	87.2 tok/s	2623 ms	124K
RAG	S	Runs well	87.2 tok/s	4036 ms	124K

Quantization options

How Mistral Small 4 119B (119B params) fits at each quantization level on AMD Instinct MI250 128GB (128.0 GB usable).

Quant	Bits	VRAM	Quality	Fit
Q2_K	2	46.4 GB	Low	A85
Q3_K_S	3	58.3 GB	Low	S87
NVFP4	4

Get started

Copy-paste commands to run Mistral Small 4 119B on your machine.

Run

lms load Mistral-Small-4-119B-2603 && lms server start

Your hardware

More models your AMD Instinct MI250 128GB can run

Model	Params	Grade	Decode	Capabilities
👁 Mistral Devstral 2 123B Instruct	123B	S	31.5 tok/s
👁 Alibaba Qwen 3.5 122B A10B	122B	S

Frequently asked questions

See all results for AMD Instinct MI250 128GB See all hardware for Mistral Small 4 119B

URL: https://willitrunai.com/can-run/mistral-small-4-119b-on-instinct-mi250-128gb

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