VOOZH about

URL: https://www.kegg.jp/entry/hsa:2565

⇱ KEGG T01001: 2565

👁 KEGG
Entry
2565              CDS       T01001                                 
Symbol
GABRG1
Name
(RefSeq) gamma-aminobutyric acid receptor subunit gamma-1 precursor
  KO
K05186  gamma-aminobutyric acid receptor subunit gamma
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04082  Neuroactive ligand signaling
hsa04519  Cadherin signaling
hsa04723  Retrograde endocannabinoid signaling
hsa04727  GABAergic synapse
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Network
nt06544  Neuroactive ligand signaling
  Element
N01887  Transport of chloride, GABAA receptor
N01891  GABAA receptor trafficking
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555 D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Cipepofol: D12449
Clobazam: D01253<JP/US>
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Darigabat: D12146
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Dimdazenil: D13231
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Fludiazepam: D01354
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286
Flutoprazepam: D01279
Gaboxadol: D04282
Ganaxolone: D04300<US>
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP/US> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP/US> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Zuranolone: D11793<JP/US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2565 (GABRG1)
   04082 Neuroactive ligand signaling
    2565 (GABRG1)
   04519 Cadherin signaling
    2565 (GABRG1)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2565 (GABRG1)
   04723 Retrograde endocannabinoid signaling
    2565 (GABRG1)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2565 (GABRG1)
   05033 Nicotine addiction
    2565 (GABRG1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2565 (GABRG1)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2565 (GABRG1)
SSDB
Motif
Pfam: Neur_chan_LBD Neur_chan_memb SP85_N
Other DBs
NCBI-GeneID: 2565
NCBI-ProteinID: NP_775807
OMIM: 137166
HGNC: 4086
Ensembl: ENSP00000295452.4
UniProt: Q8N1C3
LinkDB
Position
4:complement(46035769..46124054)
AA seq 465 aa
MGPLKAFLFSPFLLRSQSRGVRLVFLLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIH
EGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWF
DSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTL
RLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAF
VGLRNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVP
ARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSN
QKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNISVPQEDDYGYQCLEGKDCASFFCCFE
DCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
NT seq 1398 nt   +upstreamnt  +downstreamnt
atgggtcctttgaaagcttttctcttctccccttttcttctgcggagtcaaagtagaggg
gtgaggttggtcttcttgttactgaccctgcatttgggaaactgtgttgataaggcagat
gatgaagatgatgaggatttaacggtgaacaaaacctgggtcttggccccaaaaattcat
gaaggagatatcacacaaattctgaattcattgcttcaaggctatgacaataaacttcgt
ccagatataggagtgaggcccacagtaattgaaactgatgtttatgtaaacagcattgga
ccagttgatccaattaatatggaatatacaatagatataatttttgcccaaacctggttt
gacagtcgtttaaaattcaatagtaccatgaaagtgcttatgcttaacagtaatatggtt
ggaaaaatttggattcctgacactttcttcagaaactcaagaaaatctgatgctcactgg
ataacaactcctaatcgtctgcttcgaatttggaatgatggacgagttctgtatactcta
agattgacaattaatgcagaatgttatcttcagcttcataactttcccatggatgaacat
tcctgtccactggaattttcaagctatggataccctaaaaatgaaattgagtataagtgg
aaaaagccctccgtagaagtggctgatcctaaatactggagattatatcagtttgcattt
gtagggttacggaactcaactgaaatcactcacacgatctctggggattatgttatcatg
acaattttttttgacctgagcagaagaatgggatatttcactattcagacctacattcca
tgcattctgacagttgttctttcttgggtgtctttttggatcaataaagatgcagtgcct
gcaagaacatcgttgggtatcactacagttctgactatgacaaccctgagtacaattgcc
aggaagtctttacctaaggtttcttatgtgactgcgatggatctctttgtttctgtttgt
ttcatttttgtttttgcagccttgatggaatatggaaccttgcattattttaccagcaac
caaaaaggaaagactgctactaaagacagaaagctaaaaaataaagcctcgatgactcct
ggtctccatcctggatccactctgattccaatgaataatatttctgtgccgcaagaagat
gattatgggtatcagtgtttggagggcaaagattgtgccagcttcttctgttgctttgaa
gactgcagaacaggatcttggagggaaggaaggatacacatacgcattgccaaaattgac
tcttattctagaatatttttcccaaccgcttttgccctgttcaacttggtttattgggtt
ggctatctttacttataa

DBGET integrated database retrieval system