Intel Xeon 6300 vs. AMD EPYC 4005 SMT/HT Performance
First up with the NAMD molecular biology software, SMT on the AMD EPYC 4345P yielded a nearly 16% boost to its performance thanks to SMT while the Intel Xeon 6369P only went up by 6%. The AMD EPYC 4005 series is already much faster than the Intel Xeon 6300 series for NAMD 3.0 in general thanks to the AMD Zen 5 CPUs supporting AVX-512.
With Altair's OpenRadioss software, Hyper Threading did provide some sizable benefits for the Xeon 6369P while the EPYC 4345P performance was unchanged. But notable here is that even with/without SMT, the EPYC 4345P 8-core processor was faster than the Xeon 6369P flagship.
With the miniBUDE HPC benchmark the AMD EPYC Grado performance is much faster thanks to AVX-512 while SMT provides some minor benefits on both the Intel Xeon 6 and AMD EPYC Zen 5 processors.
Importantly, leveraging SMT didn't increase the CPU power use.