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LY75

Identifiers

LY75, CD205, CLEC13B, DEC-205, GP200-MR6, LY-75, lymphocyte antigen 75

External IDs

OMIM: 604524; MGI: 106662; HomoloGene: 31085; GeneCards: LY75; OMA:LY75 - orthologs

Gene location (Human)
👁 Chromosome 2 (human)
Chr.	Chromosome 2 (human)^[1]
👁 Chromosome 2 (human) 👁 Genomic location for LY75 👁 Genomic location for LY75
Band	2q24.2	Start	159,803,355 bp^[1]
Band	2q24.2	End	159,904,756 bp^[1]

Gene location (Mouse)
👁 Chromosome 2 (mouse)
Chr.	Chromosome 2 (mouse)^[2]
👁 Chromosome 2 (mouse) 👁 Genomic location for LY75 👁 Genomic location for LY75
Band	2\|2 C1.1	Start	60,122,447 bp^[2]
Band	2\|2 C1.1	End	60,213,647 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

thymus

epithelium of nasopharynx

jejunal mucosa

bronchial epithelial cell

mucosa of paranasal sinus

nasal epithelium

skin of thigh

mucosa of sigmoid colon

lactiferous duct

pancreatic ductal cell

Top expressed in

granulocyte

thymus

primitive streak

yolk sac

lumbar spinal ganglion

jejunum

duodenum

tail of embryo

epiblast

blood

More reference expression data

BioGPS

👁 Image
More reference expression data

Gene ontology
Molecular function	protein binding carbohydrate binding transmembrane signaling receptor activity signaling receptor activity
Cellular component	integral component of membrane integral component of plasma membrane extracellular exosome membrane
Biological process	inflammatory response endocytosis immune response signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4065


17076

Ensembl


ENSG00000054219


ENSMUSG00000026980

UniProt


O60449


Q60767

RefSeq (mRNA)


NM_002349


NM_013825

RefSeq (protein)


NP_001185688 NP_001185689


NP_038853

Location (UCSC)

Chr 2: 159.8 – 159.9 Mb

Chr 2: 60.12 – 60.21 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

CD205 also called Lymphocyte antigen 75 is a protein that in humans is encoded by the LY75 gene.^[5]^[6]^[7]

CD205 is also known as DEC-205.

References

[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000054219 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026980 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kato M, Neil TK, Clark GJ, Morris CM, Sorg RV, Hart DN (Jun 1998). "cDNA cloning of human DEC-205, a putative antigen-uptake receptor on dendritic cells". Immunogenetics. 47 (6): 442–50. doi:10.1007/s002510050381. PMID 9553150. S2CID 10949216.
^ "Entrez Gene: LY75 lymphocyte antigen 75".
^ Ronan, Henry. "cd keys". Retrieved 22 June 2024.

Tungekar MF, Gatter KC, Ritter MA (1996). "Bladder carcinomas and normal urothelium universally express gp200-MR6, a molecule functionally associated with the interleukin 4 receptor (CD 124)". Br. J. Cancer. 73 (4): 429–32. doi:10.1038/bjc.1996.77. PMC 2074450. PMID 8595155.
al-Tubuly AA, Luqmani YA, Shousha S, et al. (1996). "Differential expression of gp200-MR6 molecule in benign hyperplasia and down-regulation in invasive carcinoma of the breast". Br. J. Cancer. 74 (7): 1005–11. doi:10.1038/bjc.1996.481. PMC 2077117. PMID 8855966.
McKay PF, Imami N, Johns M, et al. (1999). "The gp200-MR6 molecule which is functionally associated with the IL-4 receptor modulates B cell phenotype and is a novel member of the human macrophage mannose receptor family". Eur. J. Immunol. 28 (12): 4071–83. doi:10.1002/(SICI)1521-4141(199812)28:12<4071::AID-IMMU4071>3.0.CO;2-O. PMID 9862343. S2CID 13656389.
Palmer DB, Crompton T, Marandi MB, et al. (1999). "Intrathymic function of the human cortical epithelial cell surface antigen gp200-MR6: single-chain antibodies to evolutionarily conserved determinants disrupt mouse thymus development". Immunology. 96 (2): 236–45. doi:10.1046/j.1365-2567.1999.00691.x. PMC 2326733. PMID 10233701.
Guo M, Gong S, Maric S, et al. (2000). "A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells". Hum. Immunol. 61 (8): 729–38. doi:10.1016/S0198-8859(00)00144-0. PMID 10980384.
Kato M, Neil TK, Fearnley DB, et al. (2000). "Expression of multilectin receptors and comparative FITC-dextran uptake by human dendritic cells". Int. Immunol. 12 (11): 1511–9. doi:10.1093/intimm/12.11.1511. PMID 11058570.
Kato M, Khan S, Gonzalez N, et al. (2003). "Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1". J. Biol. Chem. 278 (36): 34035–41. doi:10.1074/jbc.M303112200. PMID 12824192.
Bozzacco L, Trumpfheller C, Siegal FP, et al. (2007). "DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1289–94. Bibcode:2007PNAS..104.1289B. doi:10.1073/pnas.0610383104. PMC 1783096. PMID 17229838.
Nonaka D, Henley JD, Chiriboga L, Yee H (2007). "Diagnostic utility of thymic epithelial markers CD205 (DEC205) and Foxn1 in thymic epithelial neoplasms". Am. J. Surg. Pathol. 31 (7): 1038–44. doi:10.1097/PAS.0b013e31802b4917. PMID 17592270. S2CID 30502411.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350
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References

Further reading