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⇱ PRKG1 - Wikipedia


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Protein-coding gene in the species Homo sapiens
PRKG1
👁 Image
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1ZXA, 3OCP, 3OD0, 3OGJ, 4KU7, 4KU8, 4QX5, 4QXK, 4R4L, 4R4M, 4Z07

Identifiers
AliasesPRKG1, AAT8, PKG, PRKG1B, PRKGR1B, cGK, cGK 1, cGK1, cGKI, cGKI-BETA, cGKI-alpha, protein kinase, cGMP-dependent, type I, PKG1, protein kinase cGMP-dependent 1
External IDsOMIM: 176894; MGI: 108174; HomoloGene: 55964; GeneCards: PRKG1; OMA:PRKG1 - orthologs
Gene location (Human)
👁 Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Band10q11.23-q21.1Start50,990,888 bp[1]
End52,298,423 bp[1]
Gene location (Mouse)
👁 Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Band19|19 C1Start30,541,889 bp[2]
End31,742,433 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • saphenous vein

  • biceps brachii

  • Skeletal muscle tissue of biceps brachii

  • Descending thoracic aorta

  • ascending aorta

  • Skeletal muscle tissue of rectus abdominis

  • right coronary artery

  • popliteal artery

  • urethra

  • tibial arteries
Top expressed in
  • spermatid

  • lumbar spinal ganglion

  • epithelium of lens

  • trigeminal ganglion

  • soleus muscle

  • sternocleidomastoid muscle

  • digastric muscle

  • temporal muscle

  • intercostal muscle

  • zygote
More reference expression data
BioGPS
👁 Image


👁 Image
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5592

19091

Ensembl

ENSG00000185532

ENSMUSG00000052920

UniProt

Q13976

P0C605

RefSeq (mRNA)

NM_001098512
NM_006258
NM_001374781
NM_001374782

NM_001013833
NM_011160

RefSeq (protein)

NP_001091982
NP_006249
NP_001361710
NP_001361711

NP_001013855
NP_035290

Location (UCSC)Chr 10: 50.99 – 52.3 MbChr 19: 30.54 – 31.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

cGMP-dependent protein kinase 1, alpha isozyme is an enzyme that in humans is encoded by the PRKG1 gene.[5][6][7]

Interactions

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PRKG1 has been shown to interact with:

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185532Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052920Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sandberg M, Natarajan V, Ronander I, Kalderon D, Walter U, Lohmann SM, Jahnsen T (Sep 1989). "Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat". FEBS Letters. 255 (2): 321–9. Bibcode:1989FEBSL.255..321S. doi:10.1016/0014-5793(89)81114-7. PMID 2792381. S2CID 83233954.
  6. ^ Orstavik S, Sandberg M, Bérubé D, Natarajan V, Simard J, Walter U, Gagné R, Hansson V, Jahnsen T (April 1992). "Localization of the human gene for the type I cyclic GMP-dependent protein kinase to chromosome 10". Cytogenetics and Cell Genetics. 59 (4): 270–3. doi:10.1159/000133267. PMID 1544322.
  7. ^ "Entrez Gene: PRKG1 protein kinase, cGMP-dependent, type I".
  8. ^ Casteel DE, Zhuang S, Gudi T, Tang J, Vuica M, Desiderio S, Pilz RB (Aug 2002). "cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I". The Journal of Biological Chemistry. 277 (35): 32003–14. doi:10.1074/jbc.M112332200. PMID 12082086.
  9. ^ a b Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (Mar 2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature. 404 (6774): 197–201. Bibcode:2000Natur.404..197S. doi:10.1038/35004606. PMID 10724174. S2CID 205004996.
  10. ^ Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J (Jun 2001). "Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta". The Journal of Biological Chemistry. 276 (26): 24153–9. doi:10.1074/jbc.M101530200. PMID 11309393.
  11. ^ Tang KM, Wang GR, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME, Tang M, Wang G (Dec 2003). "Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure". Nature Medicine. 9 (12): 1506–12. doi:10.1038/nm958. PMID 14608379. S2CID 20331752.
  12. ^ Yuasa K, Michibata H, Omori K, Yanaka N (Dec 1999). "A novel interaction of cGMP-dependent protein kinase I with troponin T". The Journal of Biological Chemistry. 274 (52): 37429–34. doi:10.1074/jbc.274.52.37429. PMID 10601315.

Further reading

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