VOOZH about

URL: https://simple.wikipedia.org/wiki/Chlorpromazine

⇱ Chlorpromazine - Simple English Wikipedia, the free encyclopedia

Jump to content
From Simple English Wikipedia, the free encyclopedia
Chlorpromazine
πŸ‘ Skeletal formula of chlorpromazine
πŸ‘ Ball-and-stick model of the chlorpromazine molecule
Clinical data
Trade namesLargactil, Thorazine, many others
AHFS/Drugs.comMonograph
MedlinePlusa682040
License data
Pregnancy
category
  • AU:C
Routes of
administration		Oral (tablets and syrup available), rectal, IM, IV infusion
ATC code
Legal status
Legal status
  • Ingeneral: β„ž(Prescription only)
Pharmacokinetic data
Bioavailability10–80% (Oral; large interindividual variation)[1]
Protein binding90–99%[1]
MetabolismLiver, mostly CYP2D6-mediated[1]
Elimination half-life30 hours
ExcretionUrine (43–65% in 24 hrs)[1]
Identifiers
  • 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-propan-1-amine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.042 πŸ‘ Edit this at Wikidata
Chemical and physical data
FormulaC17H19ClN2S
Molar mass318.86 g/mol (free base)
355.33 g/mol (hydrochloride)
3D model (JSmol)
  • CN(C)CCCN1c2ccccc2Sc3c1cc(cc3)Cl
  • InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3πŸ‘ check
    Y
  • Key:ZPEIMTDSQAKGNT-UHFFFAOYSA-NπŸ‘ check
    Y
(verify)
πŸ‘ Image
An advert for Thorazine (which contains Chlorpromazine) from the 1960s.

Chlorpromazine, also known by its trade name Thorazine, is an antipsychotic drug. It is typically made to treat Schizophrenia, and treat bipolar disorder in the past[when?]. It has been shown to help uncontrollable hiccups disappear. It is also used to help with nausea and vomiting.[2] Chlorpromazine was developed in 1950, making it the oldest antipsychotic drug.[3]

References

[change | change source]
  1. 1 2 3 4 "PRODUCT INFORMATION LARGACTIL" (PDF). TGA eBusiness Services. Sanofi Aventis Pty Ltd. 28 August 2012. Archived from the original on 30 March 2017. Retrieved 8 December 2013.
  2. ↑ "ChlorproMAZINE Monograph for Professionals". Drugs.com. Retrieved 2022-09-22.
  3. ↑ LΓ³pez-MuΓ±oz, Francisco; Alamo, Cecilio; cuenca, Eduardo; Shen, Winston; Clervoy, Patrick; Rubio, Gabriel (2005-07-01). "History of the Discovery and Clinical Introduction of Chlorpromazine". Annals of Clinical Psychiatry. 17 (3): 113–135. doi:10.1080/10401230591002002. ISSN1040-1237. PMID16433053.


πŸ‘ Image
 This short article about medicine can be made longer. You can help Wikipedia by adding to it.
Categories:
Hidden categories: