Immunology articles from across Nature Portfolio

B cells display a range of effector and memory phenotypes, antibody isotypes and affinities. We show that during malaria parasite infection, individual, activated clones commonly combine early, class-switch recombination, clonal expansion, effector fate bifurcation and somatic hypermutation to rapidly diversify in vivo.

The identification of an alveolar epithelial-like subset of medullary thymic epithelial cells (mTECs) reveals a key mechanism that orchestrates mTEC heterogeneity, thereby maintaining central immune tolerance.

Crosslinked ionizable lipids enable mRNA lipid nanoparticles to metabolically reprogram immune cells to elicit strong vaccine responses while reducing inflammatory side effects.

Cao et al. report that whole β-glucan particles (WGP) enhance BCG-conditioned macrophage antigen handling and presentation. WGP plus BCG strengthens CD4⁺ memory-associated responses and improves bacterial control while reducing lung inflammation

Oncolytic virotherapy represents a promising approach for glioma therapy with challenges remain. Here, the authors show that IDH1-mutant gliomas exhibit increased susceptibility to oncolytic HSV-1 therapy due to impaired antiviral signaling, and that combining virotherapy with TIGIT blockade enhances antitumor immune responses and therapeutic efficacy.

Inducing ferroptosis enhances the response to cancer immunotherapy. Here, the authors show that disrupting fatty acid oxidation at the HADHA node promotes tumor ferroptosis via accumulation of the intermediate C18-OH. Consequently, the clinically approved HADHA inhibitor trimetazidine promotes ferroptosis and potentiates immunotherapeutic efficacy.

B cells display a range of effector and memory phenotypes, antibody isotypes and affinities. We show that during malaria parasite infection, individual, activated clones commonly combine early, class-switch recombination, clonal expansion, effector fate bifurcation and somatic hypermutation to rapidly diversify in vivo.

A preprint by Teodoro-Castro et al. reports a nuclear role for STING in impairing DNA replication and contributing to replication stress in ageing pathologies.

Functional profiling of autoantibodies from individuals with long COVID demonstrates a casual link with neurological symptoms, reframing long COVID as, at least in part, an antibody-mediated disease.

The identification of an alveolar epithelial-like subset of medullary thymic epithelial cells (mTECs) reveals a key mechanism that orchestrates mTEC heterogeneity, thereby maintaining central immune tolerance.

Crosslinked ionizable lipids enable mRNA lipid nanoparticles to metabolically reprogram immune cells to elicit strong vaccine responses while reducing inflammatory side effects.