Protein-coding gene in the species Homo sapiens
Protein ENL is a protein that in humans is encoded by the MLLT1 gene.[5]
MLLT1 has been shown to interact with CBX8.[6]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000130382 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024212 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1".
- ^ García-Cuéllar MP, Zilles O, Schreiner SA, Birke M, Winkler TH, Slany RK (January 2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. PMID 11313972.
- Tkachuk DC, Kohler S, Cleary ML (November 1992). "Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias". Cell. 71 (4): 691–700. doi:10.1016/0092-8674(92)90602-9. PMID 1423624. S2CID 11801536.
- Thirman MJ, Levitan DA, Kobayashi H, Simon MC, Rowley JD (December 1994). "Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia". Proceedings of the National Academy of Sciences of the United States of America. 91 (25): 12110–4. Bibcode:1994PNAS...9112110T. doi:10.1073/pnas.91.25.12110. PMC 45386. PMID 7991593.
- Rubnitz JE, Morrissey J, Savage PA, Cleary ML (September 1994). "ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells". Blood. 84 (6): 1747–52. doi:10.1182/blood.V84.6.1747.1747. PMID 8080983.
- Yamamoto K, Seto M, Komatsu H, Iida S, Akao Y, Kojima S, Kodera Y, Nakazawa S, Ariyoshi Y, Takahashi T (October 1993). "Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia". Oncogene. 8 (10): 2617–25. PMID 8378076.
- Lavau C, Luo RT, Du C, Thirman MJ (September 2000). "Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice". Proceedings of the National Academy of Sciences of the United States of America. 97 (20): 10984–9. Bibcode:2000PNAS...9710984L. doi:10.1073/pnas.190167297. PMC 27135. PMID 10995463.
- García-Cuéllar MP, Zilles O, Schreiner SA, Birke M, Winkler TH, Slany RK (January 2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. PMID 11313972.
- Nie Z, Yan Z, Chen EH, Sechi S, Ling C, Zhou S, Xue Y, Yang D, Murray D, Kanakubo E, Cleary ML, Wang W (April 2003). "Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Molecular and Cellular Biology. 23 (8): 2942–52. doi:10.1128/MCB.23.8.2942-2952.2003. PMC 152562. PMID 12665591.
- Gué M, Sun JS, Boudier T (January 2006). "Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited". BMC Cancer. 6 20. doi:10.1186/1471-2407-6-20. PMC 1388228. PMID 16433901.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Meyer C, Burmeister T, Strehl S, Schneider B, Hubert D, Zach O, Haas O, Klingebiel T, Dingermann T, Marschalek R (March 2007). "Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia". Leukemia. 21 (3): 588–90. doi:10.1038/sj.leu.2404542. PMID 17252016. S2CID 34843802.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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(1) Basic domains |
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| (1.1) Basic leucine zipper (bZIP) | |
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| (1.2) Basic helix-loop-helix (bHLH) | | Group A | |
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| Group B | |
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Group C
bHLH-PAS | |
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| Group D | |
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| Group E | |
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Group F
bHLH-COE | |
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| (1.3) bHLH-ZIP | |
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| (1.4) NF-1 | |
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| (1.5) RF-X | |
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| (1.6) Basic helix-span-helix (bHSH) | |
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| (2.1) Nuclear receptor (Cys4) | | subfamily 1 | |
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| subfamily 2 | |
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| subfamily 3 | |
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| subfamily 4 | |
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| subfamily 5 | |
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| subfamily 6 | |
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| subfamily 0 | |
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| (2.2) Other Cys4 | |
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| (2.3) Cys2His2 | |
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| (2.4) Cys6 | |
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| (2.5) Alternating composition | |
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| (2.6) WRKY | |
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(4) β-Scaffold factors with minor groove contacts |
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(0) Other transcription factors |
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