Protein-coding gene in the species Homo sapiens
Neurogenin-2 is a protein that in humans is encoded by the NEUROG2 gene.[5]
Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis.[6]
It has been found to reprogram astrocytes into glutamatergic neurons when expressed.[7]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000178403 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027967 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: neurogenin 2".
- ^ Heng JI, Nguyen L, Castro DS, Zimmer C, Wildner H, Armant O, et al. (September 2008). "Neurogenin 2 controls cortical neuron migration through regulation of Rnd2". Nature. 455 (7209): 114–118. Bibcode:2008Natur.455..114H. doi:10.1038/nature07198. PMID 18690213. S2CID 2813030.
- ^ Liu F, Zhang Y, Chen F, Yuan J, Li S, Han S, et al. (March 2021). "Neurog2 directly converts astrocytes into functional neurons in midbrain and spinal cord". Cell Death & Disease. 12 (3): 225. doi:10.1038/s41419-021-03498-x. PMC 7921562. PMID 33649354.
- Gradwohl G, Fode C, Guillemot F (November 1996). "Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors". Developmental Biology. 180 (1): 227–241. doi:10.1006/dbio.1996.0297. PMID 8948587.
- Simmons AD, Horton S, Abney AL, Johnson JE (January 2001). "Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers". Developmental Biology. 229 (2): 327–339. doi:10.1006/dbio.2000.9984. PMID 11203697.
- Kumar M, Bagchi B, Gupta SK, Meena AS, Gressens P, Mani S (August 2007). "Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells". Stem Cells and Development. 16 (4): 667–681. doi:10.1089/scd.2006.0115. PMID 17784840.
- Deng S, Deng H, Le W, Xu H, Yang H, Deng X, et al. (January 2010). "Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease". Neuroscience Letters. 468 (3): 195–197. doi:10.1016/j.neulet.2009.10.078. PMID 19879328. S2CID 27698762.
- Park CH, Kang JS, Yoon EH, Shim JW, Suh-Kim H, Lee SH (March 2008). "Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro". FEBS Letters. 582 (5): 537–542. Bibcode:2008FEBSL.582..537P. doi:10.1016/j.febslet.2008.01.018. PMID 18242186. S2CID 33390799.
- Fode C, Gradwohl G, Morin X, Dierich A, LeMeur M, Goridis C, et al. (March 1998). "The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons". Neuron. 20 (3): 483–494. doi:10.1016/S0896-6273(00)80989-7. PMID 9539123. S2CID 16790307.
|
|---|
(1) Basic domains |
|---|
| (1.1) Basic leucine zipper (bZIP) | |
|---|
| (1.2) Basic helix-loop-helix (bHLH) | | Group A | |
|---|
| Group B | |
|---|
Group C
bHLH-PAS | |
|---|
| Group D | |
|---|
| Group E | |
|---|
Group F
bHLH-COE | |
|---|
|
|---|
| (1.3) bHLH-ZIP | |
|---|
| (1.4) NF-1 | |
|---|
| (1.5) RF-X | |
|---|
| (1.6) Basic helix-span-helix (bHSH) | |
|---|
|
|
|
|---|
| (2.1) Nuclear receptor (Cys4) | | subfamily 1 | |
|---|
| subfamily 2 | |
|---|
| subfamily 3 | |
|---|
| subfamily 4 | |
|---|
| subfamily 5 | |
|---|
| subfamily 6 | |
|---|
| subfamily 0 | |
|---|
|
|---|
| (2.2) Other Cys4 | |
|---|
| (2.3) Cys2His2 | |
|---|
| (2.4) Cys6 | |
|---|
| (2.5) Alternating composition | |
|---|
| (2.6) WRKY | |
|---|
|
|
|
(4) β-Scaffold factors with minor groove contacts |
|---|
|
|
(0) Other transcription factors |
|---|
|
|
|
