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Protein-coding gene in the species Homo sapiens
NKX2-3
Identifiers
AliasesNKX2-3, CSX3, NK2.3, NKX2.3, NKX2C, NKX4-3, NK2 homeobox 3
External IDsOMIM: 606727; MGI: 97348; HomoloGene: 17061; GeneCards: NKX2-3; OMA:NKX2-3 - orthologs
Gene location (Human)
👁 Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Band10q24.2Start99,532,942 bp[1]
End99,536,524 bp[1]
Gene location (Mouse)
👁 Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Band19 C3|19 36.67 cMStart43,600,764 bp[2]
End43,604,331 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • muscle layer of sigmoid colon

  • spleen

  • transverse colon

  • duodenum

  • sural nerve

  • minor salivary glands

  • jejunal mucosa

  • mucosa of transverse colon

  • cecum

  • rectum
Top expressed in
  • Hindgut

  • migratory enteric neural crest cell

  • yolk sac

  • Stomodeum

  • buccopharyngeal membrane

  • duodenum

  • pharyngeal pouch

  • ileum

  • tongue

  • embryo
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

159296

18089

Ensembl

ENSG00000119919

ENSMUSG00000044220

UniProt

Q8TAU0

P97334

RefSeq (mRNA)

NM_145285

NM_008699

RefSeq (protein)

NP_660328

NP_032725

Location (UCSC)Chr 10: 99.53 – 99.54 MbChr 19: 43.6 – 43.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein Nkx-2.3 is a protein that in humans is encoded by the NKX2-3 gene.[5][6][7]

NKX2C is a member of the NKX family of homeodomain-containing transcription factors, which are implicated in many aspects of cell type specification and maintenance of differentiated tissue functions.[7]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119919Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044220Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Price M, Lazzaro D, Pohl T, Mattei MG, Ruther U, Olivo JC, Duboule D, Di Lauro R (Mar 1992). "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain". Neuron. 8 (2): 241–55. doi:10.1016/0896-6273(92)90291-K. PMID 1346742. S2CID 22766848.
  6. ^ Pabst O, Schneider A, Brand T, Arnold HH (Jul 1997). "The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development". Dev Dyn. 209 (1): 29–35. doi:10.1002/(SICI)1097-0177(199705)209:1<29::AID-AJA3>3.0.CO;2-Z. PMID 9142493.
  7. ^ a b "Entrez Gene: NKX2-3 NK2 transcription factor related, locus 3 (Drosophila)".

Further reading

[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.